Immunopathogenesis of Coronavirus-Induced Acute Respiratory Distress Syndrome (ARDS): Potential Infection-Associated Hemophagocytic Lymphohistiocytosis
发布时间：2021-06-02
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影响因子：22.556
教研室：Department of Pathophysiology
发表刊物：Clin Microbiol Rev.
项目来源：the National Natural Science Foundation of China (NSFC)
关键字：acute respiratory distress syndrome; hemophagocytic lymphohistiocytosis; human coronavirus.
摘要：The outbreak of coronavirus disease 2019 (COVID-19) in December 2019 in Wuhan, China, introduced the third highly pathogenic coronavirus into humans in the 21st century. Scientific advance after the severe acute respiratory syndrome coronavirus (SARS-CoV) epidemic and Middle East respiratory syndrome coronavirus (MERS-CoV) emergence enabled clinicians to understand the epidemiology and pathophysiology of SARS-CoV-2. In this review, we summarize and discuss the epidemiology, clinical features, and virology of and host immune responses to SARS-CoV, MERS-CoV, and SARS-CoV-2 and the pathogenesis of coronavirus-induced acute respiratory distress syndrome (ARDS). We especially highlight that highly pathogenic coronaviruses might cause infection-associated hemophagocytic lymphohistiocytosis, which is involved in the immunopathogenesis of human coronavirus-induced ARDS, and also discuss the potential implication of hemophagocytic lymphohistiocytosis therapeutics for combating severe coronavirus infection.
第一作者：Chao Quan,Caiyan Li,Han Ma
论文类型：其它
通讯作者：Yisha Li,Huali Zhang（通讯作者）
学科门类：医学
期号：2020 Oct 14;34(1):e00074-20.
是否译文：否
发表时间：2020-10-14
收录刊物：SCI