Sex-differential modulation of visceral pain by brain derived neurotrophic factor (BDNF) in rats.
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Release time:2020-06-28 Impact Factor:2.026 DOI number:10.1016/j.neulet.2010.05.013 Affiliation of Author(s):Xiang-Ya College of Medicine, Central South University Teaching and Research Group:Department of Anatomy and Neurobiology, Journal:Neuroscience letters Place of Publication:荷兰 Funded by:Natural Science Foundation of China (NSFC: 30700790) Key Words:Visceral pain
BDNF
Acetic acid
Gender difference Abstract:In spite of the fact that brain derived neurotrophic factor (BDNF) has been reported to be implicated
in the development of visceral pain, it remains to be determined whether the role of BDNF in pain is
gender dependent. The present study investigated the effect of BDNF on visceral pain in different gender
rats. A model for visceral pain was established by intraperitoneal (i.p.) injection of acetic acid (AA)
into Sprague–Dawley rats: males, females and females with an ovariectomy (OVX). The pain behavior
index was assessed by counting the number of abdominal contractions for 60 min after i.p. injection of
AA. Anti-BDNF antibody, or BDNF, was administered 1 h before the AA injection to examine the role of
BDNF in visceral pain. After the AA injection, the number of abdominal contraction was dramatically
increased in all rats but females showed more severe pain behavior than males. The higher sensitivity to
AA-induced nocifensive response was attenuated by OVX. Pretreatment with anti-BDNF antibody significantly
exacerbated the nocifensive response in males but attenuated it in females. While exogenous BDNF
administration did not alter AA injection-induced nocifensive response in females, BDNF pretreatment
attenuated the nocifensive response in males but exacerbated it in females with OVX. The present study
suggests there is a gender dichotomy in visceral pain induced by AA injection. In addition, the modulation
of visceral pain by BDNF is also sex dependent, i.e., BDNF facilitates the visceral pain in female rats but
displays an opposite effect in male rats. Our results may have important implications in the management
of clinical pain. Note:to R. Dai and Undergraduate Innovative Experiment
Program of Central South University (0810533128). Indexed by:Journal paper Document Code:20470867 Discipline:生物学 Document Type:J Volume:3 Issue:478 Page Number:184–7 Number of Words:4095 ISSN No.:0304-3940 Translation or Not:no Date of Publication:2010-07-12 Included Journals:SCI Links to published journals:https://pubmed.ncbi.nlm.nih.gov/20470867/ -
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