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DOI码：10.1016/j.neulet.2010.05.013

所属单位：Xiang-Ya College of Medicine, Central South University

教研室：Department of Anatomy and Neurobiology,

发表刊物：Neuroscience letters

刊物所在地：荷兰

项目来源：Natural Science Foundation of China (NSFC: 30700790)

关键字：Visceral pain BDNF Acetic acid Gender difference

摘要：In spite of the fact that brain derived neurotrophic factor (BDNF) has been reported to be implicated in the development of visceral pain, it remains to be determined whether the role of BDNF in pain is gender dependent. The present study investigated the effect of BDNF on visceral pain in different gender rats. A model for visceral pain was established by intraperitoneal (i.p.) injection of acetic acid (AA) into Sprague–Dawley rats: males, females and females with an ovariectomy (OVX). The pain behavior index was assessed by counting the number of abdominal contractions for 60 min after i.p. injection of AA. Anti-BDNF antibody, or BDNF, was administered 1 h before the AA injection to examine the role of BDNF in visceral pain. After the AA injection, the number of abdominal contraction was dramatically increased in all rats but females showed more severe pain behavior than males. The higher sensitivity to AA-induced nocifensive response was attenuated by OVX. Pretreatment with anti-BDNF antibody significantly exacerbated the nocifensive response in males but attenuated it in females. While exogenous BDNF administration did not alter AA injection-induced nocifensive response in females, BDNF pretreatment attenuated the nocifensive response in males but exacerbated it in females with OVX. The present study suggests there is a gender dichotomy in visceral pain induced by AA injection. In addition, the modulation of visceral pain by BDNF is also sex dependent, i.e., BDNF facilitates the visceral pain in female rats but displays an opposite effect in male rats. Our results may have important implications in the management of clinical pain.

备注：to R. Dai and Undergraduate Innovative Experiment Program of Central South University (0810533128).

论文类型：期刊论文

论文编号：20470867

学科门类：生物学

文献类型：J

卷号：3

期号：478

页面范围：184–7

字数：4095

ISSN号：0304-3940

是否译文：否

发表时间：2010-07-12

收录刊物：SCI

发布期刊链接：https://pubmed.ncbi.nlm.nih.gov/20470867/