A targeted therapy for melanoma by graphene oxide composite with microRNA carrier

Release time:2019-04-15

Affiliation of Author(s):中南大学湘雅三医院

Journal:Drug Design, Development and Therapy

Abstract:Background:Nowadays, the combination of microRNA (miR) is attracting increased attention in clinical cancer trials. However, the clinical use of miR is highly limited because of certain properties such as instability, low-specificity distribution, and metabolic toxicity. Methods:In order to improve the anti-tumor efficacy and reduce the side effects of miR in treating melanoma, a combination of graphene oxide (GO), chitosan (CS), and a cellular penetrating peptide, MPG, was prepared with solid dispersion method in this research. The research has analyzed the specific components of nano drug-

Co-author:Jianda Zhou, Shijie Tang, Xiaoqing Chen, Jingang Yu, Huiqing Xie, Can Liu

Document Code:PMID：30275686

Discipline:临床医学

Volume:2018:12

Issue:2018:12

Page Number:3095–3106

Translation or Not:no