The role of MicroRNAs in tendon injury, repair, and related tissue engineering.
发布时间：2023-02-27
点击次数：
发表刊物：Biomaterials
关键字：Antiadhesion; Biomaterials; MicroRNAs (miRNAs); Tendon healing; Tendon injuries; Tissue engineering.
摘要：Tendon injuries are one of the most common musculoskeletal disorders that cause considerable morbidity and significantly compromise the patients' quality of life. The innate limited regenerative capacity of tendon poses a substantial treating challenge for clinicians. MicroRNAs (miRNAs) are a family of small non-coding RNAs that play a vital role in orchestrating many biological processes through post-transcriptional regulation. Increasing evidence reveals that miRNA-based therapeutics may serve as an innovative strategy for the treatment of tendon pathologies. In this review, we briefly present miRNA biogenesis, the role of miRNAs in tendon cell biology and their involvement in tendon injuries, followed by a summary of current miRNA-based approaches in tendon tissue engineering with a special focus on attenuating post-injury fibrosis. Next, we discuss the advantages of miRNA-functionalized scaffolds in achieving sustained and localized miRNA administration to minimize off-target effects, and thus hoping to inspire the development of effective miRNA delivery platforms specifically for tendon tissue engineering. We envision that advancement in miRNA-based therapeutics will herald a new era of tendon tissue engineering and pave a way for clinical translation for the treatments of tendon disorders.
合写作者：Zhu Y, Zhu W, Zhang G, Yang YP
第一作者：Liu Q
论文类型：期刊论文
通讯作者：Zhao C
期号：277
页面范围：121083
是否译文：否
发表时间：2021-10-01