Structural and functional evolution of IL-1 targeting: From systemic neutralization to bioengineered nanotherapies

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Impact Factor:10.2

DOI number:10.1016/j.mtbio.2026.103057

Affiliation of Author(s):中南大学生命科学学院

Teaching and Research Group:医学遗传学

Journal:Materials Today Bio

Place of Publication:Netherlands

Key Words:Interleukin-1; Antibody; Variable new antigen receptor; Structure-function coevolution; Targeted therapy

Abstract:The interleukin-1 (IL-1) superfamily mediates critical inflammatory responses. Monoclonal antibodies against IL-1alpha and IL-1beta have transformed the management of autoinflammatory and cardiovascular disease, yet their efficacy is limited by poor tissue penetration, compensatory cytokine networks and immunosuppression. This review traces the evolution of IL-1 therapeutics, examines barriers restricting conventional immunoglobulins in necrotic and fibrotic tissue, and discusses bispecific dual blockade and the shift toward single-domain antibodies with stimuli-responsive nanocarriers.

Note:JCR Q1，IF 10.2

Co-author:Guodong Chen, Zhengbing Lyu

First Author:Lan Yang

Indexed by:Journal Article

Discipline:Natural Science

First-Level Discipline:Biology

Document Type:Review

Volume:38

Page Number:103057

ISSN No.:2590-0064

Translation or Not:no

Date of Publication:2026-03-25