中南大学
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返回首页MSL2 disruption leads to autism-like behaviors, impairs neurogenesis, and alters histone H4K16 acetylation
发布时间：2026-05-22
点击次数：
- 影响因子：
- 6.2
- DOI码：
- 10.1007/s00018-026-06237-7
- 所属单位：
- 中南大学生命科学学院
- 教研室：
- 医学遗传学
- 发表刊物：
- Cellular and Molecular Life Sciences
- 刊物所在地：
- Switzerland
- 关键字：
- Epigenetics; MSL2; Neurodevelopmental disorders; Neurogenesis; Neocortex
- 摘要：
- Neurodevelopmental disorders (NDDs) often involve dysregulated epigenetics, and variants in MSL complex components including MSL2 have been implicated, yet the mechanisms remain unclear. Using nervous-system-specific Msl2 knockout mice and multi-omics profiling, we show that Msl2 deficiency impairs social novelty recognition, learning and memory, with disrupted neocortical lamination and reduced progenitor proliferation and migration. Msl2-deficient brains show reduced H4K16ac and loss of chromatin accessibility at NDD genes, linking MSL2 to chromatin state and neurodevelopment.
- 备注：
- JCR Q1，IF 6.2
- 合写作者：
- 陈国栋, 郭辉, Kun Xia
- 第一作者：
- Shengjie Luo
- 论文类型：
- Journal Article
- 通讯作者：
- Shiyi Qu, Senwei Tan, Zhuo Song, Yongqing Lv, Xiangbin Jia, Jieqiong Tan
- 学科门类：
- 理学
- 一级学科：
- 生物学
- 文献类型：
- Research Article
- 卷号：
- 83
- 期号：
- 1
- 页面范围：
- 283
- ISSN号：
- 1420-682X
- 是否译文：
- 否
- 发表时间：
- 2026-05-22