中南大学
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返回首页5-Hydroxymethylcytosine: Far Beyond the Intermediate of DNA Demethylation
发布时间：2024-11-02
点击次数：
- 影响因子：
- 4.9
- DOI码：
- 10.3390/ijms252111780
- 所属单位：
- 中南大学生命科学学院
- 教研室：
- 医学遗传学
- 发表刊物：
- International Journal of Molecular Sciences
- 刊物所在地：
- Switzerland
- 关键字：
- 5hmC; 5mC; demethylation; TET; transcription regulation
- 摘要：
- Epigenetics is pivotal in gene expression regulation and cellular differentiation. DNA methylation is a well-known epigenetic mark, and the discovery of 5-hydroxymethylcytosine (5hmC) has given new insight into cytosine modifications. 5hmC, oxidized from 5-methylcytosine (5mC), acts both as an intermediate of demethylation and as a stable genomic modification. This review summarizes the functions of 5hmC in development and disease, its potential as a diagnostic and prognostic marker, and the latest methods for detecting and quantifying 5hmC.
- 备注：
- JCR Q1，IF 4.9
- 合写作者：
- 陈国栋
- 第一作者：
- Kaixi Zheng
- 论文类型：
- Journal Article
- 通讯作者：
- Zhengbing Lyu, Jianqing Chen
- 学科门类：
- 理学
- 一级学科：
- 生物学
- 文献类型：
- Review
- 卷号：
- 25
- 期号：
- 21
- 页面范围：
- 11780
- ISSN号：
- 1422-0067
- 是否译文：
- 否
- 发表时间：
- 2024-11-02