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影响因子：

4.9

DOI码：

10.3390/ijms252312879

所属单位：

中南大学生命科学学院

教研室：

医学遗传学

发表刊物：

International Journal of Molecular Sciences

刊物所在地：

Switzerland

关键字：

IgNAR; VNAR; nurse shark; nanobody

摘要：

The variable domain of IgNAR shows great potential in biological medicine and therapy. IgNAR has been found in sharks and rays, and the nurse shark (Ginglymostoma cirratum) IgNAR is the most extensively studied. Although identified over 30 years ago, its characteristics and genomic localization remain poorly defined. We localized the IgNAR loci in the nurse shark genome, resolving previously missing regions and identifying three loci (GcIgNAR1-3), of which only GcIgNAR1 and GcIgNAR2 are expressed. AlphaFold3-modelled structures confirmed the loci, advancing IgNAR research in nurse sharks.

备注：

JCR Q1，IF 4.9

合写作者：

陈国栋

第一作者：

Wenjie Tang, Kaixi Zheng

论文类型：

Journal Article

通讯作者：

Shengjie Sun, Bo Zhong, Zhan Luo, Junjie Yang, Lei Jia, Lan Yang, Wenna Shang, Xiaofeng Jiang, Zhengbing Lyu, Jianqing Chen

学科门类：

理学

一级学科：

生物学

文献类型：

Research Article

卷号：

25

期号：

23

页面范围：

12879

ISSN号：

1422-0067

是否译文：

否

发表时间：

2024-11-29