Enantioselectivity-Switchable Organocatalytic [4+ 2]-Annulation to Access the Spirooxindole–Norcamphor Scaffold
发布时间：2021-07-02
点击次数：
DOI码：10.1021/acs.orglett.0c04164
发表刊物：Organic Letters
摘要：An organocatalyzed enantiodivergent synthesis of a multifunctionalized spirooxindole–norcamphor scaffold via a [4 + 2]-annulation between cyclicα, β-unsaturated ketone and methylene indolinones has been established. The presence of CaCl2 in DMF could reverse the enantioselectivity to facilely deliver the enantiomers of the corresponding spirooxindoles. Both enantiomers of the corresponding spirooxindoles were obtained in excellent yield and diastereo-/enantioselectivity by employing one single prolinosulfonamide catalyst.
合写作者：Xian-Zhou Zheng, Jun-An Xiao, Hao-Yue Xiang
第一作者：Jing Wan
论文类型：期刊论文
通讯作者：Kai Chen*, Xiao-Qing Chen*, Hua Yang*
卷号：23
期号：3
页面范围：963-968
是否译文：否
发表时间：2021-01-22
发布期刊链接：https://pubs.acs.org/doi/abs/10.1021/acs.orglett.0c04164