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陈晓青，女，博士，二级教授，博士生导师，享受国务院政府特殊津贴。中南大学“531”二层次人才，“食品药品分子科学研究中心”主任。致力于生物、环境复杂体系分离分析，手性对映体识别与分离分析，生物、环境与食品安全即时检测（POCT）的研发。在Angew. Chem. Int. Ed., Anal. Chem., Chem. Commun., Org. Lett. 等国际权威刊物上发表SCI收录论文300余篇，其中ESI高被引论文12篇(ORCID: 0000-0002-8768-8965)，H指数为54。入围职业生涯全球top 2%科学家（主学科：分析化学，副学科：有机化学）。主持承担国家自然科学基金面上项目7项、及其他纵、横向项目近40项。2020年获湖南省自然科学二等奖1项，2013年获湖南省发明二等奖1项，2003年获湖南省进步一等奖1项。授权发明专利9项。

近年来代表性科研论文:

2024：

[1] Machine learning-assisted "shrink-restricted" SERS strategy for classification of environmental nanoplastics-induced cell death, Environmental Science & Technology 2024, doi.org/10.1021/acs.est.4c05590

[2] An Endogenous mRNA-powered and Spatial Confinement-derived DNA Nanomachine for Ultra-rapid and Sensitive Imaging of Let-7a, Analytical Chemistry 2024, 96, 564-571

[3] Au/Pt@ZIF-90 Nanoenzyme Capsule based "Explosive" Signal Amplifier for "All-in-Tube" POCT, Analytical Chemistry 2024, 96, 1362-1370

[4] Hydrogen bonding-induced aggregation of chiral functionalized AuNS@Ag NPs for photothermal enantioanalysis, Analytical Chemistry 2024, 96, 6292-6300

[5] Nanoenzyme Hydrogel Film Based Portable Point-of-Care Testing Platform for Double-Signal Visual Detection of PSA, Analytical Chemistry 2024, 96, 9909−9916

[6] Synergy of target-induced magnetic network and single-drop chromogenic system for ultrasensitive "All-in-Tube" detection of miRNA in whole blood, Analytical Chemistry 2024, 96, 12012−12021

[7] Machine learning-aided 3D dynamic SERS strategy for physiological mapping: biotoxicity of environmentally dimensional aged nanoplastics and corresponding protein corona complexes, Analytical Chemistry 2024, 96, 16629−16638

[8] A Stimuli-Responsive Photoluminescent Molecular Tweezer for Highly Enantioselective Discrimination of Chiral Primary Amines, Analytical Chemistry 2024, acs.analchem.4c02891

[9] A Nanocage Reactor with Dense Shareable Hot Spots for in-situ and Dynamic SERS Tracking Photocatalytic Reaction Bonds Variations Chemical Engineering Journal 2024, 489, 151358

[10] Interfacially crystallized Enzyme@MOFs biocatalytic membranes for highly efficient synthesis of D-amino acids via continuously recirculating stereoinversion, Chemical Engineering Journal 2024, 497, 154529

[11] Tartaric acid-derived chiral carbon nanodots for catalytic enantioselective ring-opening reactions of styrene oxide, Chemical Communications  2024, 60, 10382-10385

[12] Photoinduced, Palladium-Catalyzed Enantioselective 1,2-Alkylsulfonylation of 1,3-Dienes, ACS Catalysis 2024, 14(5), 3725–3732.

2023：

[1] Quinine-Fabricated Surface-Enhanced Raman Spectroscopy Chiral Sensing Platform Enables Simultaneous Enantioselective Discrimination and Identification of Aliphatic Amino Acids, Analytical Chemistry 2023, 95(11), 4923-4931.

[2] Endogenous mRNA-Powered and Spatial Confinement-Derived DNA Nanomachines for Ultrarapid and Sensitive Imaging of Let-7a, Analytical Chemistry, 2023, 96(1), 564–571.

[3] Pore Size Tunable Trypsin@ ZIF-90 and Hydrogel Integrated Lateral Flow Point-of-Care Platform for ATP Detection. ACS Applied Materials & Interfaces, 2023 15(17), 21690-21698.

2022：

[1] Photoredox‐Catalyzed Deoxygenation of Hexafluoroacetone Hydrate Enables Hydroxypolyfluoroalkylation of Alkenes." Angewandte Chemie International Edition 2022, 61, e2022110.

[2] Regioselective Access to Vicinal Diamines by Metal‐Free Photosensitized Amidylimination of Alkenes with Oxime Esters. Angewandte Chemie International Edition 2022, 61,  e2022122.

[3] Deep Learning-Based Label-Free Surface-Enhanced Raman Scattering Screening and Recognition of Small-Molecule Binding Sites in Proteins. Analytical Chemistry 2022, 94(33), 11483-11491.

[4] Framework Nucleic Acid-Based Spatial-Confinement Amplifier for miRNA Imaging in Living Cells, Analytical Chemistry 2022, 94(6): 2934-2941

[5] Deep learning-based multicapturer SERS platform on plasmonic nanocube metasurfaces for multiplex detection of organophosphorus pesticides in environmental water. Analytical Chemistry 2022, 94(46), 16006-16014.

[6] Facile construction of a reusable multi-enzyme cascade bioreactor for effective fluorescence discrimination and quantitation of amino acid enantiomers, Chemical Engineering Journal 2022, 428: 131975.

2021：

[1] Simultaneous In Situ Extraction and Self-Assembly of Plasmonic Colloidal Gold Superparticles for SERS Detection of Organochlorine Pesticides in Water, Analytical Chemistry 2021, 93(10): 4657-4665

[2] AIEgen modulated per-functionalized flower-like IRMOF-3 frameworks with tunable light emission and excellent sensing properties, Chemical Communications 2021, 57: 2392-2395

[3] Framework nucleic acid programmed combinatorial delivery nanocarriers for parallel and multiplexed analysis, Chemical Communications 2021, 57, 10935-10938

[4] Photocatalytic Cyclization/Defluorination Domino Sequence to Access 3-Fluoro-1,5-dihydro-2H-pyrrol-2-one Scaffold, Organic Letters 2021, 23(12): 4754-4758

[5] Phosphonium ylide-mediated programmable fluorination to access mono-and difluoromethylarenes, Organic Letters 2021, 23(7): 2538-2542

[6] O-Perhalopyridin-4-yl Hydroxylamines: Amidyl-Radical Generation Scaffolds in Photoinduced Direct Amination of Heterocycles, Organic Letters 2021, 23(5): 1643-1647

[7] Enantioselectivity-Switchable Organocatalytic [4+ 2]-Annulation to Access the Spirooxindole–Norcamphor Scaffold, Organic Letters 2021, 23(3): 963-968

2020:
[1] Integrating Target-Triggered Aptamer-Capped HRP@ Metal–Organic Frameworks with a Colorimeter Readout for On-Site Sensitive Detection of Antibiotics, Analytical Chemistry 2020, 92(20): 14259–14266.

[2] l-Pyroglutamic Acid-Modified CdSe/ZnS Quantum Dots: A New Fluorescence-Responsive Chiral Sensing Platform for Stereospecific Molecular Recognition, Analytical Chemistry 2020, 92(17): 12040-12048.

[3] “Pomegranate-like” plasmonic nanoreactors with accessible high-density hotspots for in situ SERS monitoring of catalytic reactions, Analytical Chemistry 2020, 92(5): 4115-4122.
[4] Photoinduced Single‐Electron Transfer as an Enabling Principle in the Radical Borylation of Alkenes with NHC–Borane, Angewandte Chemie International Edition 2020, 59: 6706 –6710.

[5] Photocatalytic C–F bond borylation of polyfluoroarenes with NHC-boranes, Organic Letters 2020, 22(5): 1742-1747.

[6] Phosphine-mediated MBH-type/umpolung addition domino sequence: Divergent construction of coumarins, Organic Letters 2020, 22(2): 488-492.

[7] AIE-active metal–organic frameworks: Facile preparation, tunable light emission, ultrasensitive sensing of copper (II) and visual fluorescence detection of glucose, Journal of Materials Chemistry C 2020, 8: 10408-10415

2019:
[1] Development of a “dual gates” locked, target-triggered nanodevice for point-of-care testing with a glucometer readout, ACS Sensors 2019, 4(4): 968-976.
[2] Intelligent platform for simultaneous detection of multiple aminoglycosides based on a ratiometric paper-based device with digital fluorescence detector readout, ACS Sensors 2019, 4(12): 3283-3290.
[3] Organocatalytic, Enantioselective, Polarity-Matched Ring-Reorganization Domino Sequence Based on the 3‑Oxindole Scaffold, Organic Letters 2019, 21(7): 2166-2170.
[4] Photocatalytic, phosphoranyl radical-mediated N–O cleavage of strained cycloketone oximes, Organic Letters 2019, 21(8): 2658-2662.
[5] Rapid and visual detection of aflatoxin B1 in foodstuffs using aptamer/G-quadruplex DNAzyme probe with low background noise, Food Chemistry 2019, 271: 581-587.
2018:
[1] Valency‐Controlled Framework Nucleic Acid Signal Amplifiers, Angewandte Chemie International Edition 2018, 57, 7131-7135.
[2] Simultaneous in situ extraction and fabrication of surface-enhanced Raman scattering substrate for reliable detection of thiram residue, Analytical Chemistry 2018, 90(22): 13647-13654.
[3] Visible-Light-Induced External Radical-Triggered Annulation To Access CF2-Containing Benzoxepine Derivatives, Organic Letters 2018, 20(5): 1363-1366.
[4] Unraveling and manipulating the stereospecific retro-aldol reaction in the organocatalytic asymmetric aldol reaction of isatin and cyclohexanone, Organic Letters 2018, 20(23): 7535-7538.
[5] 4-Mercaptophenylboronic acid-modified spirally-curved mesoporous silica nanofibers coupled with ultra performance liquid chromatography–mass spectrometry for determination of brassinosteroids in plants, Food Chemistry 2018, 263: 51-58.
[6] A magnetic pH-induced textile fabric with switchable wettability for intelligent oil/water separation, Chemical Engineering Journal 2018, 347: 52-63.
2017-2015:
[1] Synthesis of multi-Au-nanoparticle-embedded mesoporous silica microspheres as self-filtering and reusable substrates for SERS detection, ACS Applied Materials & Interfaces 2017, 9(48): 42156-42166.
[2] Discovery of temperature-dependent, autoinductive reversal of enantioselectivity: palladium-mediated [3+ 3]-annulation of 4-hydroxycoumarins, Chemical Communications 2017, 53(32): 4441-4444.
[3] Fetal bovine serum influences the stability and bioactivity of resveratrol analogues: A polyphenol-protein interaction approach, Food Chemistry 2017, 219: 321-328.
[4] Amide-assisted intramolecular [3+ 2] annulation of cyclopropane ring-opening: a facile and diastereoselective access to the tricyclic core of (±)-scandine, Chemical Communications 2016, 52(10): 2177-2180.
[5] Programmable engineering of a biosensing interface with tetrahedral DNA nanostructures for ultrasensitive DNA detection, Angewandte Chemie International Edition 2015, 54(7): 2151-2155. 
[6] Microbial biotransformation of bioactive flavonoids, Biotechnology Advances 2015, 33(1): 214-223
[7] Visible-Light-Driven, Radical-Triggered Tandem Cyclization of o-Hydroxyaryl Enaminones: Facile Access to 3-CF2 /CF3-Containing Chromones, Organic Letters 2016, 19(1): 146-149.
[8] Non-covalent interaction between dietary stilbenoids and human serum albumin: Structure–affinity relationship, and its influence on the stability, free radical scavenging activity and cell uptake of stilbenoids, Food Chemistry 2016, 202: 383-388.
[9] Type 2 diabetes diminishes the benefits of dietary antioxidants: Evidence from the different free radical scavenging potential, Food Chemistry 2015, 186: 106-112.
[10] Separation of polyphenols from leaves of Malus hupehensis (Pamp.) Rehder by off-line two-dimensional high speed counter-current chromatography combined with recycling elution mode, Food Chemistry 2015, 186: 139-145.
[11] Separation of five flavonoids from tartary buckwheat (Fagopyrum tataricum (L.) Gaertn) grains via off-line two dimensional high-speed counter-current chromatography, Food Chemistry 2015, 186: 153-159.
[12] Macrocyclic β-cyclodextrin derivative-based aqueous-two phase systems: phase behaviors and applications in enantioseparation, Chemical Engineering Science 2016, 143: 1-11.

[1] 生物、环境复杂体系分离分析： a. 新型功能SERS（表面增强拉曼光谱）基底设计与SERS高灵敏现场快速检测；b.基于MOFs/FNA/量子点设计合成功能探针，开发细胞功能分子的原位成像检测方法，实现生物/环境复杂体系中超痕量靶标的分析检测。

[2] 手性对映体识别与分离分析：a. 手性识别模块的设计：基于三点作用原理设计合成手性识别模块，阐述其手性作用原理，构建手性模块功能化纳米材料实现手性分离分析；b. 手性纳米材料：基于手性作用原理刻蚀组装手性纳米材料，并应用于手性光学识别。

[3] 生物、环境与食品安全智能检测 （POCT）：a. 便携智能化检测系统：基于功能化量子点/DNA纳米技术/核酸适体，结合微流控技术，构建基于智能终端的微型便携式食品安全电化学/光学检测系统，实现农残及环境污染物智能髙通量电化学/光学检测。 b. 纸基即时检测：基于功能化纳米材料设计具有微流体通道的纸基微流控芯片，开发纸基芯片的多重（光/电/热）检测装置，实现生物、环境及食品中多靶标纸基即时检测。

[1]  2017.12- 2022.12

湖南省精密仪器测试学会第七届理事会  常务理事

[2]  2017.12- 2022.12

湖南省精密仪器测试学会色谱分会 副理事长

[1]  1986.9- 1989.6

中南工业大学 | 分析化学 | Master's degree | Master's degree

[2]  1982.9- 1986.6

中南工业大学 | 冶金化学分析 | University graduated | Bachelor's degree

[3]  2003.9- 2006.12

中南大学 | 应用化学 | PhD Graduate | Doctoral degree

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