Coaxial Electrostatic Spray-Based Preparation of Localization Missile Liposomes on a Microfluidic Chip for Targeted Treatment of Triple-Negative Breast Cancer
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Release time:2025-02-16 Impact Factor:5.8 DOI number:10.1016/j.ijpharm.2023.123220 Affiliation of Author(s):Xiangya School of Pharmaceutical Sciences in Central South University, Changsha, Hunan, China Journal:International Journal of Pharmaceutics Place of Publication:荷兰 Key Words:Anti-cancer; Coaxial electrostatic spray; Liposome; Microfluidic chip; TNBC. Abstract:Due to triple-negative breast cancer (TNBC) lacking specific targets for efficient therapies, nanoparticles have been widely developed to enhance efficacy and reduce the toxicity of chemotherapeutics. We prepared unique liposomes containing PTX and DOX by microfluidics-based coaxial electrostatic spray method, which have a uniform particle size, high drug loading capacity, and good stability. Meanwhile, the cRGD peptide was fused with the lipid membrane to form PTX/DOX@cRGD-Lipo, which played a GPS role in locating tumor neovascularization and further targeting TNBC cells where both overexpress αvβ3. The PTX/DOX@cRGD-Lipo showed synergistic anti-tumor activity of double drugs and enhanced tumor cell apoptosis. Fluorescence microscopy and flow cytometry showed that the co-loaded targeted liposomes could be effectively absorbed by MDA-MB-231 and 4T1 cells and then released the content. In addition, the PTX/DOX@cRGD-Lipo presented excellent targeting biodistribution in vivo and a higher tumor growth inhibition rate in the orthotopic tumor mouse model. All results suggested that the double drug-loaded targeted liposome could be a promising treatment modality for TNBC. Co-author:W. Xu, Q. Li, C. He, Y. Liu, J. Liu, R. Wang, J. Wu First Author:Q. Wang Indexed by:Journal paper Correspondence Author:D. Xiang, C. Chen Discipline:Medicine First-Level Discipline:Pharmaceutical Science Document Type:电子版 Volume:643 Page Number:123220 ISSN No.:1873-3476 Translation or Not:no Date of Publication:2023-07-10 -
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