Application of microfluidic technology based on surface-enhanced Raman scattering in cancer biomarker detection: A review

Release time:2025-02-16

Impact Factor:1.8

DOI number:10.1016/j.jpha.2023.08.009

Affiliation of Author(s):Xiangya School of Pharmaceutical Sciences in Central South University, Changsha, Hunan, China

Journal:Journal of Pharmaceutical Analysis

Place of Publication:荷兰

Key Words:Cancer biomarkersMicrofluidic technologySurface-enhanced Raman scattering

Abstract:With the continuous discovery and research of predictive cancer-related biomarkers, liquid biopsy shows great potential in cancer diagnosis. Surface-enhanced Raman scattering (SERS) and microfluidic technology have received much attention among the various cancer biomarker detection methods. The former has ultrahigh detection sensitivity and can provide a unique fingerprint. In contrast, the latter has the characteristics of miniaturization and integration, which can realize accurate control of the detection samples and high-throughput detection through design. Both have the potential for point-of-care testing (POCT), and their combination (lab-on-a-chip SERS (LoC-SERS)) shows good compatibility. In this paper, the basic situation of circulating proteins, circulating tumor cells, exosomes, circulating tumor DNA (ctDNA), and microRNA (miRNA) in the diagnosis of various cancers is reviewed, and the detection research of these biomarkers by the LoC-SERS platform in recent years is described in detail. At the same time, the challenges and future development of the platform are discussed at the end of the review. Summarizing the current technology is expected to provide a reference for scholars engaged in related work and interested in this field.

Co-author:I. Shaw

First Author:C. Nie

Indexed by:综述论文

Correspondence Author:C. Chen

Discipline:Medicine

First-Level Discipline:Pharmaceutical Science

Document Type:电子版

Volume:13

Issue:12

Page Number:1429-1451

ISSN No.:2214-0883

Translation or Not:no

Date of Publication:2023-08-23