Fang Zhu, Hao Bo et. al Trace the profile and function of circular RNAs in Sertoli cell only syndrome
发布时间：2021-06-04
点击次数：
DOI码：10.1016/j.ygeno.2021.04.022
发表刊物：Aging
关键字：Circular RNA ,High-throughput sequencing ,Sertoli cell-only syndrome ,Spermatogenesis
摘要：Studies increasingly show the involvement of circular RNAs (circRNAs) in several diseases. This study aims to explore the circRNA expression pattern in the testicular tissues of patients with Sertoli only cell syndrome (SCOS) and their potential functions. High throughput circRNA microarray analysis indicated that 399 circRNAs were upregulated and 1195 were down-regulated (fold change >2, P < 0.05) in SCOS relative to obstructive azoospermia (OA). The hsa_circRNA_101222, hsa_circRNA_001387, hsa_circRNA_001153, hsa_circRNA_101373 and hsa_circRNA_103864 were validated by qRT-PCR. Furthermore, the hosting genes of the differentially expressed circRNAs (DEcircRNAs) were enriched in biological processes related to cell cycle and intercellular communication. Also, the overlapping genes between the hosting genes of SCOS-related DEcircRNAs and those highly expressed in Sertoli cells of non-obstructive azoospermia (NOA) were enriched in immune cell development and cell communication. Taken together, aberrantly expressed circRNAs likely mediate SCOS development by regulating the function of Sertoli cells and the spermatogenic microenvironment.
论文类型：基础研究
是否译文：否
发表时间：2021-04-12
收录刊物：SCI