• Terry
    Position:vice director
  • Doctor's Degree
  • Biology
  • vice director
  • Molecular Biology Department/Biological Laboratory Center, School of Life Science
 

Education Experience

  • 2005.12007.8

     国际遗传工程与生物技术中心(意大利地里雅斯特)   生物学 

  • 1999.92003.10

     Central South University   Biochemistry and Molecular Biology   Doctor's Degree 

  • 1996.91999.6

     Hunan medical University   Biochemistry and Molecular Biology   Master's Degree 

  • 1989.91992.6

     Hunan medical college   Department of laboratory medicine 

Job Experience

  • 2016.9Now

     生命科学学院生物化学系   中南大学   系副主任 

  • 2013.92016.8

     Molecular Biology Department, School of Life Science   Central South University   Vice director 

  • 2011.92013.8

     Research Center, School of Biological Science and Technology   Central South University 

  • 2010.92011.8

     Municipal Government/Science and Technology Bureau of Jintan City/Jincheng town   Jintan City in Jiangsu Province   Mayor assistant/Party members/Deputy director of the Science and Technology Bureau of Jintan City/Deputy Party Secretary of Jincheng town, Jintan City in Jiangsu Province 

  • 2007.92010.8

     Molecular Biology Research Center, School of Biological Science and Technology   Central South University 

  • 2005.12007.8

     Leukocyte Biology   International Center for Genetic Engineering and Biotechnology(ICGEB) 

  • 2004.92005.1

     Molecular Biology Research Center, School of Biological Science and Technology   Central South University 

  • 2001.92004.8

     Molecular Biology Research Center, School of Biological Science and Technology   Central South University 

  • 1999.72001.8

     Molecular Biology Research Center, School of Biological Science and Technology   Central South University 

  • 1992.71996.8

     Department of Laboratory Medical Science   the second affiliated hospital of Hunan medical University 

Team

Social Appointments

  • - Science and technology review expert of China's Ministry of Education

  • - Science and technology assessment expert of Italy Ministry of Health

  • - peer review expert of life science section and medicine science section of National Natural Science Foundation of China

  • - The Ministry of education degree and postgraduate education evaluation expert

  • -  multiple Provincial Natural Science Fund Assessment Expert

  • - Reviewer of several international and domestic journals

  • - review expert of Health and Family Planning Commission of Hunan Province

  • - Member of Chinese society of Biochemistry and Molecular biology

  • - Member of the Chinese society of Microbiology

  • - Member of the Chinese society of Immunology

 

Introduction

TANG Li-Jun, ph.D, Professor
MAJOR: Biochemistry & Molecular Biology
MAILING ADDRESS: tljxie@csu.edu.cn
Research Experience:
During Master degree train Period I was working on the mechanism of IFN-α and IFN-αcombined with GM-CSF treated CML patients. IFN-α and IFN-α plus GM-CSF can inhibit the expression of anti-apoptosis gene such as bcr-abl and bcl-2, and regulate the expression of c-myc. It is the possible mechanism that IFN-α treatment or combined treatment on CML at chronic phase can inhibit the malignant clone expansion by promoting cell death.
During Ph.D train Period I engaged in disease-related gene clone and functional analysis by EST technique and gene chips. I cloned several novel gene and carried on preliminary functional analysis of these genes which are involved in the development of human multiple myeloma.
As a post-doctor in ICGEB I engaged in protein pattern analysis of human body fluid (e.g. vaginal fluid, pleural effusion) by using 2-DE MALDI TOF/TOF MS. I was also working on the mechanism of macrophage against mycobacterium through reactive oxygen species activity, toll-like receptor activity, ER stress activity and other cellular activity.
After postdoc train I came back China and worked on macrophage’s defense mycobacterium through exosomes which was secreted from cells. Exosome is a very important carrier and has lots of function especially in charge of cells communication. The role of exosomes shed from Myco- bacterium avium sp. paratuberculosis-infected macrophages in intercellular communication processes was examined. We compared the responses of resting macrophages infected with Mycobacterium avium sp. paratuberculosis with those of resting macrophages treated with exosomes previously released from macrophages infected with Mycobacterium avium sp. paratuberculosis. Both Mycobacterium avium sp. paratuberculosis and exosomes from infected-cells enhanced the expression of CD80 and CD86 and the secretion of TNF-α and IFN-γby macrophages. Two-dimensional analysis of the proteins present in exosomes from Mycobacterium avium sp. paratuberculosis-infected macrophages compared with those from resting cells resulted in the identification by MALDI TOF/TOF mass spectrometry of the following differentially expressed proteins: two actin isoforms, guanine nucleotide-binding protein-1, cofilin-1 and peptidyl-prolyl cis-trans isomerase A.

  • Entry Time:1992-07-01
  • Graduated University:Central South University
  • Honor& Award:1.2011-2012 Postgraduate Teaching Quality Excellence Award,Central South University,
    2.2011-2012 Undergraduate Teaching Quality Excellence Award,Central South University,
    3.2008-2009 Undergraduate Teaching Quality Excellence Award,Central South University
  • Office Location:Molecular Biology Department,Xiangya campus,Central South University,Xiangya Road 110#,Changsha 410078,Hunan,China
  • Contact:E-mail:tljxie@csu.edu.cn
PV: