中文
  • Terry
  • Doctoral degree
  • Researcher
  • Life Sciences
 

Educational Background

  • 2005.12007.8

     国际遗传工程与生物技术中心(意大利地里雅斯特)   生物学   博士后 

  • 1999.92003.10

     Central South University   Biochemistry and Molecular Biology   Doctoral degree   PhD Graduate 

  • 1996.91999.6

     Hunan medical University   Biochemistry and Molecular Biology   Master's degree   Master's degree 

Work Experience

  • 2019.7Now

    中南大学      生命科学学院生物化学与分子生物学系    研究员

  • 2016.92019.6

    中南大学      生命科学学院生物化学系    系副主任    研究员

  • 2013.92016.8

    Central South University      Molecular Biology Department, School of Life Science    Vice director    professor

  • 2011.92013.8

    Central South University      Research Center, School of Biological Science and Technology    Associate professor

  • 2010.92011.8

    Jintan City in Jiangsu Province      Municipal Government/Science and Technology Bureau of Jintan City/Jincheng town    Mayor assistant/Party members/Deputy director of the Science and Technology Bureau of Jintan City/Deputy Party Secretary of Jincheng town, Jintan City in Jiangsu Province    挂职锻炼

  • 2007.92010.8

    Central South University      Molecular Biology Research Center, School of Biological Science and Technology    Associate professor

  • 2005.12007.8

    International Center for Genetic Engineering and Biotechnology(ICGEB)      Leukocyte Biology    Post-doctor

  • 2004.92005.1

    Central South University      Molecular Biology Research Center, School of Biological Science and Technology    Associate professor

  • 1999.72004.8

    Central South University      Molecular Biology Research Center, School of Biological Science and Technology    Intern Researcher

  • 1992.61996.8

    湖南医科大学附二院      检验科

Research Group

  • Name of Research Group:Intercellular Signaling Transfer and Defense


    Zeng HT

    associate professor, master tutor. Research area is focus on the mechanisms of capacitation and acrosome reaction. Zeng found that CaM antagonists prevent capacitation by interfering with multiple regulatory pathways, and do so either with or without adverse effects on sperm motility and protein tyrosine phosphorylation. Zeng won the third prize of scientific and technological progress in Hunan...

    Xiong DH

    currently a doctoral student in Central South University. The main research direction is the biological characteristics of Microtus fortis and the mechanism of Microtus fortis defensing Schistosoma japonicum. Host of National Natural Science Foundation of China and Hunan Science and technology Project. Registered one piece of authorized invention patent (Ranked No. 3). Won the third place of mi...

    Luo SQ

    Ph.D, laboratory engineer. Main research direction is the pathogenesis of multiple myeloma. Participating in a number of National Natural Science Fund and Provincial Scientific Research Projects. Published 2 pieces of SCI papers as the first author.

    Xu XD

    majored in Biochemistry and Molecular Biology. I like sports very much, and sports make me happy. I like this sentence: “nothing is impossible.” So I always try my best to do everything well, and never give up easily.

    程明华

    15级硕士研究生

    汪阳

    16级硕士研究生

Social Affiliations

  • Science and technology review expert of China's Ministry of Education

  • Science and technology assessment expert of Italy Ministry of Health

  • peer review expert of life science section and medicine science section of National Natural Science Foundation of China

  • The Ministry of education degree and postgraduate education evaluation expert

  •  multiple Provincial Natural Science Fund Assessment Expert

  • 湖南省生物化学与分子生物学学会理事

  • Reviewer of several international and domestic journals

  • review expert of Health and Family Planning Commission of Hunan Province

  • Member of Chinese society of Biochemistry and Molecular biology

  • Member of the Chinese society of Microbiology

  • Member of the Chinese society of Immunology

 

Personal Information

TANG Li-Jun, ph.D, Professor
MAJOR: Biochemistry & Molecular Biology
MAILING ADDRESS: tljxie@csu.edu.cn
Research Experience:
During Master degree train Period I was working on the mechanism of IFN-α and IFN-αcombined with GM-CSF treated CML patients. IFN-α and IFN-α plus GM-CSF can inhibit the expression of anti-apoptosis gene such as bcr-abl and bcl-2, and regulate the expression of c-myc. It is the possible mechanism that IFN-α treatment or combined treatment on CML at chronic phase can inhibit the malignant clone expansion by promoting cell death.
During Ph.D train Period I engaged in disease-related gene clone and functional analysis by EST technique and gene chips. I cloned several novel gene and carried on preliminary functional analysis of these genes which are involved in the development of human multiple myeloma.
As a post-doctor in ICGEB I engaged in protein pattern analysis of human body fluid (e.g. vaginal fluid, pleural effusion) by using 2-DE MALDI TOF/TOF MS. I was also working on the mechanism of macrophage against mycobacterium through reactive oxygen species activity, toll-like receptor activity, ER stress activity and other cellular activity.
After postdoc train I came back China and worked on macrophage’s defense mycobacterium through exosomes which was secreted from cells. Exosome is a very important carrier and has lots of function especially in charge of cells communication. The role of exosomes shed from Myco- bacterium avium sp. paratuberculosis-infected macrophages in intercellular communication processes was examined. We compared the responses of resting macrophages infected with Mycobacterium avium sp. paratuberculosis with those of resting macrophages treated with exosomes previously released from macrophages infected with Mycobacterium avium sp. paratuberculosis. Both Mycobacterium avium sp. paratuberculosis and exosomes from infected-cells enhanced the expression of CD80 and CD86 and the secretion of TNF-α and IFN-γby macrophages. Two-dimensional analysis of the proteins present in exosomes from Mycobacterium avium sp. paratuberculosis-infected macrophages compared with those from resting cells resulted in the identification by MALDI TOF/TOF mass spectrometry of the following differentially expressed proteins: two actin isoforms, guanine nucleotide-binding protein-1, cofilin-1 and peptidyl-prolyl cis-trans isomerase A.

  • Researcher

  • Date of Employment:1992-07-01
  • School/Department:Life Sciences
  • Education Level:PhD Graduate
  • Business Address:Molecular Biology Department,Xiangya campus,Central South University,Xiangya Road 110#,Changsha 410078,Hunan,China
  • Sex:Male
  • Contact Information:E-mail:tljxie@csu.edu.cn
  • Degree:Doctoral degree
  • Status:Employed
  • Alma Mater:Central South University
  • Discipline:Biology
  • Honors and Titles:
  • 湖南省杰出青年基金获得者(2004);
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