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谭跃球，中南大学研究员，二级教授，医学遗传学博士，博士研究生导师。现任中南大学湘雅基础医学院生殖与干细胞工程研究所副所长，中信湘雅生殖与遗传专科医院副院长。并担任《中华医学遗传学杂志》编委，中国优生优育协会理事，中华医学会医学细胞生物学分会委员，中国遗传学会遗传咨询分会委员会委员，中国遗传学会国际交流委员会委员，湖南省医学会生殖医学分会和湖南省医学遗传学分会委员等学术职务。 发表论文 260篇，其中以一作/通讯作者 (含并列) 在包括《New England Journal of Medicine》、《Cell Discovery》、《American Journal of Human Genetics》、《Autophagy》、《Genetics in Medicine》、《Human Reproduction Update》、《Human Reproduction》、《Fertility and Sterility》、《Journal of Medical Genetics》等SCI收录期刊发表论文 120 余篇。2006年获“湖南省青年骨干教师”，2013年获“湖南省医学学科骨干人才”，2019年获“湖南省医学（医学遗传学）学科带头人”。
近 10年 代表性论文（#为通讯作者）： 1. Wang X, Tan YQ#, Liu MF#. Defective piRNA Processing and Azoospermia. N Engl J Med. 2022 Apr 28;386(17):1674-1675. 2. Li Y, Wang YY, Tan YQ, Yue QL, Guo YS, Yan RY, Meng LL, Zhai HC, Tong LX, Yuan ZH, Li W, Wang CC, Han SL, Ren S, Yan YT, Wang WX, Gao L, Tan C, Hu TY, Zhang H, Liu LY, Yang PL, Jiang WY, Ye YT, Tan HH, Wang YF, Lu CY, Li X, Xie J, Yuan GG, Cui YQ, Shen B, Wang C, Guan YC, Li W, Shi QH, Lin G, Ni T, Sun Z, Ye L, Vourekas A, Guo XJ, Lin MY, Zheng K. The landscape of RNA-binding proteins in mammalian spermatogenesis. Science. 2024 Oct 25;386(6720):eadj8172. 3. Li L, Tan YQ, Lu LY. Defective piRNA Processing and Azoospermia. N Engl J Med. 2022 Apr 28;386(17):1675-1676. 4. Tu C, Wen J, Wang W, Zhu Q, Chen Y, Cheng J, Li Z, Meng L, Li Y, He W, Tan C, Xie C, Fu S, Du J, Lu G, Lin G, Gou LT#, Tan YQ#. Loss-of-function variants in human C12orf40 cause male infertility by blocking meiotic progression. Cell Discovery. 2023;Aug 22;9(1):87. 5. Zhou S, Yuan S, Zhang J, Meng L, Zhang X, Liu S, Lu G, Lin G, Liu M#, Tan YQ#. DRC3 is an assembly adapter of the nexin-dynein regulatory complex functional components during spermatogenesis in humans and mice. Signal Transduct Target Ther. 2023 Jan 10;8(1):26. 6. Lu S, Gu Y, Wu Y, Yang S, Li C, Meng L, Yuan W, Jiang T, Zhang X, Li Y, Wang C, Liu M, Ye L, Guo X, Shen H, Yang X, Tan Y#, Hu Z#. Bi-allelic variants in human WDR63 cause male infertility via abnormal inner dynein arms assembly. Cell Discovery. 2021 Nov 16;7(1):110. 7. Tu C, Cong J, Zhang Q, He X, Zheng R, Yang X, Gao Y, Wu H, Lv M, Gu Y, Lu S, Liu C, Tian S, Meng L, Wang W, Tan C, Nie H, Li D, Zhang H, Gong F, Hu L, Lu G, Xu W, Lin G, Zhang F, Cao Y#, Tan YQ#. Bi-allelic mutations of DNAH10 cause primary male infertility with asthenoteratozoospermia in humans and mice. Am J Hum Genet. 2021 Aug 5;108(8):1466-1477. 8. Tu C, Li H, Liu X, Wang Y, Li W, Meng L, Wang W, Li Y, Li D, Du J, Lu G, Lin G#, Tan YQ#. TDRD7 participates in lens development and spermiogenesis by mediating autophagosome maturation. Autophagy. 2021 Nov; 17(11): 3848-3864. 9. Liu C, Tu C, Wang L, Wu H, Houston BJ, Mastrorosa FK, Zhang W, Shen Y, Wang J, Tian S, Meng L, Cong J, Yang S, Jiang Y, Tang S, Zeng Y, Lv M, Lin G, Li J, Saiyin H, He X, Jin L, Touré A, Ray PF, Veltman JA, Shi Q, O'Bryan MK, Cao Y, Tan YQ#, Zhang F#. Deleterious variants in X-linked CFAP47 induce asthenoteratozoospermia and primary male infertility. Am J Hum Genet. 2021 Feb 4;108(2):309-323. 10. Tan C, Meng L, Lv M, He X, Sha Y, Tang D, Tan Y, Hu T, He W, Tu C, Nie H, Zhang H, Du J, Lu G, Fan LQ, Cao Y, Lin G#, Tan YQ#. Bi-allelic variants in DNHD1 cause flagellar axoneme defects and asthenoteratozoospermia in humans and mice. Am J Hum Genet. 2022 Jan 6;109(1):157-171. 11. Xie C, Wang W, Tu C, Meng L, Lu G, Lin G, Lu LY, Tan YQ#. Meiotic recombination: insights into its mechanisms and its role in human reproduction with a special focus on non-obstructive azoospermia. Hum Reprod Update. 2022;28(6):763-797. 12. He JX, Lin XL, Tan C, Li Y, Su LL, Lin G, Tan YQ#, Tu CF#. Molecular insights into sperm head shaping and its role in human male fertility.Hum Reprod Update. 2025;31(4):307-332. 13. Liu C, Si W, Tu C, Tian S, He X, Wang S, Yang X, Yao C, Li C, Kherraf ZE, Ye M, Zhou Z, Ma Y, Gao Y, Li Y, Liu Q, Tang S, Wang J, Saiyin H, Zhao L, Yang L, Meng L, Chen B, Tang D, Zhou Y, Wu H, Lv M, Tan C, Lin G, Kong Q, Shi H, Su Z, Li Z, Yao YG, Jin L, Zheng P, Ray PF, Tan YQ*, Cao Y*, Zhang F*. Deficiency of primate-specific SSX1 induced asthenoteratozoospermia in infertile men and cynomolgus monkey and tree shrew models. Am J Hum Genet. 2023 Mar 2;110(3):516-530.( *contributed equally) 14. Wu TT, Tu CF, Feng YX, Qu WY, Chen JY, Wu H, Gao WX, Xu BY, Yu XL, Bao MY, Xu JF, Zhou NC, Hu HY, Jiang B, Xie QS, Meng LL, Tan C, Lin G, Shen C, Chen X, Guo YS, Zhou T, Liang YT, Hua R, Cao YX, Liu MX, Yu J, Huang XY, Tan YQ#,Zheng B#. A testis-specific E3 ubiquitin ligase complex governs spermiogenesis and male fertility.Nat Commun. 2026 Feb 24;17(1):3100. 15. Zhang X, Huang G, Jiang T, Meng L, Li T, Zhang G, Wu N, Chen X, Zhao B, Li N, Wu S, Guo J, Zheng R, Ji Z, Xu Z, Wang Z, Deng D, Tan Y#, Xu W#.CEP112 coordinates translational regulation of essential fertility genes during spermiogenesis through phase separation in humans and mice. Nat Commun. 2024 Sep 30;15(1):8465. 16. Zhang M, Zhang X, Tan C, Jiang T, Cao Z, Chen Y, Qiao F, Huang G, Ma C, Li H, Ye M, Wang L, Zuo L, Yu J, Li X, Zhang Y, Tan YQ#, Lin S#, Xu W#, Chen H#.METTL5 deficiency induces oligoasthenoteratozoospermia via impaired 18S rRNA m6A methylation in humans and mice.Mol Ther. 2025;33(11):5883-5900. 17. Tan YQ, Tu CF, Meng LL, Yuan SM, Sjaarda C, Luo AX, Du J, Li W, Gong F, Zhong CG, Deng HX, Lu GX, Liang P, Lin G. Loss-of-function mutations TDRD7 lead to a rare novel syndrome combining congenital cataract and non-obstructive azoospermia in humans. Genet Med. 2019;21(5):1209-1217. 18. Hu T, Meng L, Tan C, Luo C, He WB, Tu C, Zhang H, Du J, Nie H, Lu GX, Lin G, Tan YQ#. Biallelic CFAP61 variants cause male infertility in humans and mice with severe oligoasthenoteratozoospermia. J Med Genet. 2023 Feb;60(2):144-153. 19. Wang W, Su L, Meng L, He J, Tan C, Yi D, Cheng D, Zhang H, Lu G, Du J, Lin G, Zhang Q#, Tu C#, Tan YQ#. Biallelic variants in KCTD19 associated with male factor infertility and oligoasthenoteratozoospermia. Hum Reprod. 2023 May 16:dead095. doi: 10.1093/humrep/dead095. Epub ahead of print. PMID: 37192818. 20. Tu C, Meng L, Nie H, Yuan S, Wang W, Du J, Lu G, Lin G, Tan YQ#. A homozygous RPL10L missense mutation associated with male factor infertility and severe oligozoospermia. Fertil Steril. 2020 Mar;113(3):561-568.
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