Reprogramming the tumor microenvironment by genome editing for precision cancer therapy

Release time:2023-02-02

Impact Factor:41.444

DOI number:10.1186/s12943-022-01561-5

Affiliation of Author(s):Central South University

Teaching and Research Group:Department of Clinical Pharmacology

Journal:Molecular Cancer

Place of Publication:England

Funded by:National Natural Science Foundation of China

Key Words:Gene editing, TME, Precision cancer therapy, Reprogramming TME cells, Reprogramming cell-cell communication

Abstract:The tumor microenvironment (TME) is essential for immune escape by tumor cells. It plays essential roles in tumor development and metastasis. The clinical outcomes of tumors are often closely related to individual diferences in the patient TME. Therefore, reprogramming TME cells and their intercellular communication is an attractive and promising strategy for cancer therapy. TME cells consist of immune and nonimmune cells. These cells need to be manipulated precisely and safely to improve cancer therapy. Furthermore, it is encouraging that this feld has rapidly developed in recent years with the advent and development of gene editing technologies. In this review, we briefy introduce gene editing technologies and systematically summarize their applications in the TME for precision cancer therapy, includ‑ ing the reprogramming of TME cells and their intercellular communication. TME cell reprogramming can regulate cell diferentiation, proliferation, and function. Moreover, reprogramming the intercellular communication of TME cells can optimize immune infltration and the specifc recognition of tumor cells by immune cells. Thus, gene editing will pave the way for further breakthroughs in precision cancer therapy.

Co-author:Dong‑Hua Yang, Qi‑Si Lu

First Author:Ke Liu, Yan Zhan, Jia‑Jia Cui, Qian‑Ying Ouyang

Indexed by:Journal paper

Correspondence Author:Xiang‑Ping Li, Ji‑Ye Yin

Discipline:Medicine

First-Level Discipline:Pharmaceutical Science

Document Type:J

Volume:21

Issue:1

Page Number:98

ISSN No.:1476-4598

Translation or Not:no

Date of Publication:2022-04-11

Included Journals:SCI

Links to published journals:http://molecular-cancer.biomedcentral.com