Biological properties of carbon/carbon implant composites with unique manufacturing processes
发布时间：2021-07-17
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所属单位：中南大学
发表刊物：JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
关键字：Flexural Strength，Extract Liquid，Negative Control Group，Positive Control Group，Micronucleus Assay
摘要：The goal was to manufacture carbon/carbon (C/C) composites through a unique procedure with improved biocompatibility and reduced debris release. C/C composites were prepared by chemical vapor deposition, and their biological properties were analyzed. With regard to mechanical properties, compressive strength/modulus was 219.1 MPa/9.72 GPa, flexural strength/modulus was 121.63 MPa/21.9 GPa, and interlaminar sheer was 15.13 GPa. Biocompatibility testing revealed: (1) the extract liquid from the C/C composites had no effect on cell proliferation; (2) the extract had no impact on micronucleus frequency as compared with the control groups (P > 0.05); (3) in vivo, there was mild tissue inflammation after implantation within the first 2 weeks, but there was no significant difference compared with the control group (P > 0.05); (4) the implants were well integrated into the host tissue, and debris was limited. The tested samples have excellent biocompatibilities and reduced release of debris. The demonstrated changes in manufacturing procedures are promising
论文类型：期刊论文
学科门类：工学
一级学科：材料科学与工程
文献类型：J
卷号：20
期号：12
页面范围：2487-2492
是否译文：否
发表时间：2009-12-24
收录刊物：SCI