Friend or foe: RIG- I like receptors and diseases.
发布时间：2023-02-27
点击次数：
发表刊物：Autoimmun Rev
关键字：Autoimmune diseases; Autoinflammatory diseases; MDA5; RIG-I; RLRs.
摘要：Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs), which are pivotal sensors of RNA virus invasions, mediate the transcriptional induction of genes encoding type I interferons (IFNs) and proinflammatory cytokines, successfully establishing host antiviral immune response. A few excellent reviews have elaborated on the structural biology of RLRs and the antiviral mechanisms of RLR activation. In this review, we give a basic understanding of RLR biology and summarize recent findings of how RLR signaling cascade is strictly controlled by host regulatory mechanisms, which include RLR-interacting proteins, post-translational modifications and microRNAs (miRNAs). Furthermore, we pay particular attention to the relationship between RLRs and diseases, especially how RLRs participate in SARS-CoV-2, malaria or bacterial infections, how single-nucleotide polymorphisms (SNPs) or mutations in RLRs and antibodies against RLRs lead to autoinflammatory diseases and autoimmune diseases, and how RLRs are involved in anti-tumor immunity. These findings will provide insights and guidance for antiviral and immunomodulatory therapies targeting RLRs.
合写作者：Li M, Li C, Liu K
第一作者：Song J
论文类型：期刊论文
通讯作者：Zhu Y, Zhang H
卷号：21
期号：(10)
页面范围：103161
是否译文：否
发表时间：2022-10-01