Increased Dp71 in ischemia-reperfusion injured rat heart exerts anti-apoptotic role via enhancing Bcl-2
发布时间：2023-02-27
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发表刊物：Tissue Cell
关键字：Apoptosis; Bcl-2; Dp71; Ischemia-reperfusion injury.
摘要：For the first time, increased Dp71 in ischemia-reperfusion injured rat heart were identified, both Dp71 mRNA and protein reached its peak expression 8 h after reperfusion. In H2O2 stimulated H9c2 cells, Dp71 mRNA and protein gradually increased and reached a peak at 16 h. Enhanced Dp71 in H9c2 could resist H2O2-induced cell apoptosis, while Dp71 depletion accelerated the apoptosis induced by H2O2. Enhanced Bcl-2 expression and Bcl-2∕Bax protein expression ratio was identified in Dp71 overexpressed H9c2 cells, while knocking down Dp71 significantly decreased the Bcl-2 and Bcl-2∕Bax protein expression ratio. Increased Dp71 can accelerate FAK and p65 phosphorylation, which finally resulted in enhanced Bcl-2 expression and explains the highly possible cardiac protection role of Dp71.
合写作者：Zhao S, Xiao L, Wu Y, Wang Q, He S
第一作者：Zhu Y
论文类型：期刊论文
通讯作者：Tan S, Tan S
期号：79
页面范围：101951
是否译文：否
发表时间：2022-12-01