An organocatalytic enantioselective ring-reorganization domino sequence of methyleneindolinones with 2-aminomalonates

Release time:2021-07-02

DOI number:10.1039/D0QO01364A

Journal:Organic Chemistry Frontiers

Abstract:An organocatalytic enantioselective ring-reorganization domino sequence (Michael addition/intramolecular ring-opening/lactamization) of methyleneindolinones with 2-aminomalonates has been established in this work. As a result, pyrrolo[3,4-c]quinolinones bearing two to three contiguous chiral centers were efficiently assembled in high yields (up to 92%) with excellent diastereoselectivities (>20 : 1 dr) and enantioselectivities (up to >99% ee).

Co-author:Lan Zheng, Zhi-Peng Ye, Xiao-Qing Chen

First Author:Ji-Wei Ren#, Zhen-Zhen Xie#

Indexed by:Journal paper

Correspondence Author:Kai Chen*, Hao-Yue Xiang*, Hua Yang*

Discipline:Natural Science

First-Level Discipline:Chemistry

Document Type:J

Volume:8

Issue:4

Page Number:778-783

Translation or Not:no

Date of Publication:2020-12-17

Included Journals:SCI

Links to published journals:https://pubs.rsc.org/en/content/articlelanding/2021/qo/d0qo01364a/unauth#!divAbstract