邓旭，中南大学湘雅药学院教授，博士生导师，曾入选湖南省杰青、湖南省卫生健康高层次人才等，主要研究方向是基于中药来源活性成分的创新药物研究。 先后主持国家重点研发计划子课题、国家自然科学基金面上项目、科技部高端外国专家引进计划、湖南省重点研发计划等各类纵向项目10余项，以及多项企业横向合作项目。发表SCI论文60余篇，其中以第一作者/通讯作者(含共同)在Nat. Comm., Angew. Chem. Int. Ed., J. Med. Chem.等高水平期刊发表SCI论文30余篇，总被引1500余次(Google Scholar)，H指数24；申请专利20余项（第一发明人14项），其中12项已获授权;荣获2020年度德国Thieme Chemistry Journals Award国际学术奖和2023年度云南省自然科学二等奖1项。此外，邓旭博士还应邀担任Natural Products & Bioprospecting青年编委，以及Adv. Sci., Theranostics, J. Med. Chem.等30余种学术期刊审稿人。
热忱欢迎热爱天然药物化学、有志于创新天然药物研究的青年学子加入团队！
邮箱：dengxu3817@csu.edu.cn
湘雅新校区药学楼608办公室
Xu Deng, Ph.D., is a Professor and Ph.D. Supervisor at the Xiangya School of Pharmaceutical Sciences, Central South University. He has been selected as a Hunan Provincial Distinguished Young Scholar, a High-Level Health Talent of Hunan Province, and a Young Backbone Faculty Member of Hunan Provincial Universities. His primary research focuses on innovative drug discovery based on bioactive constituents derived from traditional Chinese medicine.
Dr. Deng has led more than ten competitive research projects, including subprojects of the National Key R&D Program of China, the General Program of the National Natural Science Foundation of China, the High-End Foreign Expert Introduction Program of the Ministry of Science and Technology, and the Hunan Key R&D Program, among others. He has also undertaken multiple industry–academia collaborative projects. To date, he has published over 60 SCI-indexed papers, including more than 30 as first or corresponding author (including co-first/co-corresponding) in high-impact journals such as Nature Communications, Angewandte Chemie International Edition, and Journal of Medicinal Chemistry. His work has been cited over 1,400 times (Google Scholar) with an H-index of 24. He has filed more than 20 patents (14 as first inventor), 12 of which have been granted. Dr. Deng received the 2020 Thieme Chemistry Journals Award and the 2023 Yunnan Provincial Second Prize in Natural Science.
He also serves as a Youth Editorial Board Member of Natural Products & Bioprospecting and as a reviewer for more than 30 academic journals, including Advanced Science, Theranostics, and Journal of Medicinal Chemistry.
Dr. Deng warmly welcomes motivated students passionate about natural product chemistry and innovative natural product-based drug discovery to join his team.
Email: dengxu3817@csu.edu.cn
Office: Room 608, Pharmacy Building, New Xiangya Campus, Central South University
团队介绍：简介
团队人员包括固定人员3名，博士研究生5人、硕士研究生20余人，团队成员学术被交叉互补，合作紧密，团队氛围好。。团队依托中南大学湘雅药学院和加拿大高水平大学，聚焦呼吸道相关疾病，利用有机化学、药物化学、细胞生物学、分子生物学等领域的前沿技术，开展天然产物合成和基于活性天然产物的创新药物研究，服务我国经济社会发展和国计民生需求。
通讯地址: 长沙市岳麓区桐梓坡路172号湘雅医学院药学楼608室
E-mails: dengxu3817@csu.edu.cn
个人主页： https://faculty.csu.edu.cn/dengxu/zh_CN/index.htm
Google Scholar: https://scholar.google.co.jp/citations?user=07Rw-HwAAAAJ&hl=ja
团队研究方向
1、基于中药来源活性天然产物的创新药物发现；1）抗病毒新药研发：针对新发突发性病毒（SARS-CoV-2、SARS-CoV和流感病毒等）特异性靶点及关键宿主因子，基于特有的类天然产物库，发现和创制广谱抗病毒新药；2）抗肿瘤新药研发：针对肿瘤发生发展中关键的特异性蛋白翻译后修饰靶点，基于特有的中药来源类天然产物库，发现和创制靶向抗肿瘤新药；3）靶向抗肿瘤/病毒PROTAC药物创制。
2、基于新颖结构活性天然产物的化学生物学研究：聚焦病毒感染及肿瘤等重大疾病，利用基于表型药物筛选方法，对课题组特有的类天然产物库进行筛选，发现新颖结构候选分子，以其为工具分子，结合化学生物学和多组学技术，阐明其作用靶点和机制。
3、导向活性天然产物高效合成的方法学研究：1）铜催化自由基串联环化反应及其在吲哚类天然产物高效合成中的应用；2）铑催化的碳环化反应及其在萜类天然产物合成中的应用。
