胡亮

特聘副教授

入职时间：2012-01-13

所在单位：基础医学院

学历：博士研究生毕业

性别：男

学位：博士学位

在职信息：在职

毕业院校：香港大学

   
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个人简介

我的硕士导师，中国生殖工程的创始人之一卢光琇老师曾说过：“没有生殖就没有遗传”。约10-15%育龄夫妇受到不育症困扰。其中男方因素约占30%。近年来，生殖医学领域研究进展十分迅速，随着人类基因组计划的完成和基因测序技术的飞速发展，利用遗传学技术和手段解决生殖医学领域的关键问题已成为大势所趋。

研究方向：

1. 从临床问题和病例出发，将经典遗传学技术与多组学、生物信息学等技术手段相结合，对男性不育症的遗传学病因、机制及预后展开研究；

2. 利用丰富的临床资源，关注罕见病特殊病例的致病机理研究和植入前遗传学检测新技术研究，为相关疾病的精准诊断和治疗提供依据。

学术成就：

研究成果以通讯作者或第一作者发表在EBioMedicine、Cell Death & Disease、Fertility & Sterility、Human Reproduction和Andrology等国际一流学术期刊上。主持国家自然科学基金委面上项目（项目编号：81372627、81873678）；参与国家重点研发计划“生殖健康及重大出生缺陷防控研究”重点专项（项目编号：2018YFC1003100）。作为第一发明人授权发明专利2项。担任中国医师协会医学遗传学医师分会第一届临床生殖遗传学专业委员会委员，中国遗传学会遗传咨询分会委员、遗传咨询能力建设专家委员会委员等学术任职。担任多个杂志（Journal of Assisted Reproduction and Genetics等）的审稿人。

以通讯作者或第一作者发表的部分代表性论文：

  1. Cheng D, Ibrahim H, Luo K, Gu Y, Xie P, Xiao Y, Cai J, Wu X, Lin G, Tan Y, Hu L. (2024) Characterization of cryptic complex chromosome rearrangements in balanced chromosomal rearrangement carriers and their PGT-SR clinical outcome assessments. Sci Rep. 2024 Sep 5;14(1):20705.  doi: 10.1038/s41598-024-70566-5.

  2. Zhang H, Li H, Ma S, Zhang S, Li W, Gu Y, Zhang E, Hu L. (2024) Very severe oligozoospermia with AZFc microdeletion patients may affect intracytoplasmic sperm injection clinical outcomes: A propensity score matching analysis. Reprod Med Biol. 2024 Jul 9;23(1):e12596.  doi: 10.1002/rmb2.12596.

  3. Xiao Y, Cheng D, Luo K, Li M, Tan Y, Lin G, Hu L. (2023) Evaluation of genetic risk of apparently balanced chromosomal rearrangement carriers by breakpoint characterization. J Assist Reprod Genet. 2023 Nov 23. doi: 10.1007/s10815-023-02986-7.

  4. Hu Y, Zhang R, Zhang S, Ji Y, Zhou Q, Leng L, Meng F, Gong F, Lu G, Lin G, Hu L. (2023) Transcriptomic profiles reveal the characteristics of oocytes and cumulus cells at GV, MI, and MII in follicles before ovulation. J Ovarian Res. 2023 Nov 22;16(1):225. doi: 10.1186/s13048-023-01291-2.

  5. Pi Y, Huang Z, Xu X, Zhang H, Jin M, Zhang S, Lin G, Hu L. (2023) Increases in computationally predicted deleterious variants of unknown significance and  sperm mtDNA copy numbers may be associated with semen quality. Andrology. 2023 Aug 25. doi: 10.1111/andr.13521. 

  6.  Xu X, Chen J, Zhao H, Pi Y, Lin G, Hu L. (2023) Single-Cell RNA-seq Analysis of a Human Embryonic Stem Cell to Endothelial Cell System Based on Transcription Factor Overexpression. Stem Cell Rev Rep. doi: 10.1007/s12015-023-10598-y. 

  7. Xie P, Hu X, Kong L, Mao Y, Cheng D, Kang K, Dai J, Zhao D, Zhang Y, Lu N, Wan Z, Du R, Xiong B, Zhang J, Tan Y, Lu G, Gong F, Lin G, Liang B, Du J, Hu L. (2022) A novel multifunctional haplotyping-based preimplantation genetic testing for different genetic conditions. Hum Reprod. doi: 10.1093/humrep/deac190.

  8. Xie P, Hu L, Peng Y, Tan Y, Luo K, Gong F, Lu G, Lin G. (2022) Risk Factors Affecting Alternate Segregation in Blastocysts From Preimplantation Genetic Testing Cycles of Autosomal Reciprocal Translocations. Front. Genet., 13:880208. doi: 10.3389/fgene.2022.880208.

  9. Li M, Ji Y, Wang D, Zhang Y, Zhang H, Tang Y, Lin G, Hu L. (2022) Evaluation of Laser Confocal Raman Spectroscopy as a Non-Invasive Method for Detecting Sperm DNA Contents. Front. Physiol. 13:827941. doi: 10.3389/fphys.2022.827941.

  10. Zheng W, Zhang S, Gu Y, Gong F, Kong L, Lu G, Lin G, Liang B, Hu L. (2021) Non-invasive Metabolomic Profiling of Embryo Culture Medium Using Raman Spectroscopy With Deep Learning Model Predicts the Blastocyst Development Potential of Embryos. Front Physiol. 12:777259. doi: 10.3389/fphys.2021.777259.

  11. Wang J, Zheng W, Zhang S, Yan K, Jin M, Hu H, Ma Z, Gong F, Lu G, Ren Y, Lin L, Lin G, Hu L, Liu S. (2021) An increase of phosphatidylcholines in follicular fluid implies attenuation of embryo quality on day 3 post-fertilization. BMC Biol. 19(1):200. doi: 10.1186/s12915-021-01118-w.

  12. Cheng D, Hu L, Gong F, Yuan S, Luo K, Wu X, Xie P, Lu C, Lu G, Tan YQ, Lin G. (2021) Clinical outcomes following preimplantation genetic testing and microdissecting junction region in couples with balanced chromosome rearrangement. J Assist Reprod Genet. 38(3):735-742. doi: 10.1007/s10815-020-02052-6.

  13.  Lan Y, Zhang S, Gong F, Lu C, Lin G, Hu L. (2020) The mitochondrial DNA copy number of cumulus granulosa cells may be related to the maturity of oocyte cytoplasm. Hum Reprod. 35(5):1120-1129. doi: 10.1093/humrep/deaa085.

  14. Hu L, Liang F, Cheng D, Zhang Z, Yu G, Zha J, Wang Y, Xia Q, Yuan D, Tan Y, Wang D, Liang Y, Lin G. (2020) Location of Balanced Chromosome-Translocation Breakpoints by Long-Read Sequencing on the Oxford Nanopore Platform. Front Genet. 10:1313. doi: 10.3389/fgene.2019.01313. eCollection 2019. 

  15. Zhao H, Li M, Ouyang Q, Lin G, Hu L. (2020) VEGF Promotes Endothelial Cell Differentiation from Human Embryonic Stem Cells Mainly Through PKC-ɛ/η Pathway. Stem Cells Dev. 29(2):90-99. doi: 10.1089/scd.2019.0172.

  16.  Luo K, Lan Y, Xie P, Gong F, Xiong B, Tan Y, Zhou S, Yang Z, Lin G, Hu L. (2019) Next-generation sequencing analysis of embryos from mosaic patients undergoing in vitro fertilization and preimplantation genetic testing. Fertil Steril. 112(2):291-297.e3. doi: 10.1016/j.fertnstert.2019.03.035. 

  17.  Xie P, Hu L, Tan Y, Gong F, Zhang S, Xiong B, Peng Y, Lu GX, Lin G. (2019) Retrospective analysis of meiotic segregation pattern and interchromosomal effects in blastocysts from inversion preimplantation genetic testing cycles. Fertil Steril. 112(2):336-342.e3. doi: 10.1016/j.fertnstert.2019.03.041. 

  18. Dai C, Hu L, Gong F, Tan Y, Cai S, Zhang S, Dai J, Lu C, Chen J, Chen Y, Lu G, Du J, Lin G. (2018) ZP2 pathogenic variants cause in vitro fertilization failure and female infertility. Genet Med. 2019 Feb;21(2):431-440. doi: 10.1038/s41436-018-0064-y.

  19. Hu L, Wei Y, Luo K, Xie P, Gong F, Xiong B, Tan Y, Lu G, Lin G. (2018) Clinical outcomes in carriers of complex chromosomal rearrangements: a retrospective analysis of comprehensive chromosome screening results in seven cases. Fertil Steril. 109(3):486-492.

  20. Zhao H, Zhao Y, Li Z, Ouyang Q1, Sun Y, Zhou D, Xie P, Zeng S, Dong L, Wen H, Lu G, Lin G, Hu L. (2018) FLI1 and PKC co-activation promote highly efficient differentiation of human embryonic stem cells into endothelial-like cells. Cell Death and Diseases. 9(2):131. doi: 10.1038/s41419-017-0162-9. 

  21. Dou D, Zhao H, Li Z, Xu L, Xiong X, Wu X, Sun Y, Zeng S, Ouyang Q, Zhou D, Ma N, Lin G, Hu L. (2017) CHD1L promotes neuronal differentiation in human embryonic stem cells by upregulating PAX6. Stem Cells Dev. 26(22):1626-1636.

  22. Hu L, Cheng D, Gong F, Lu C, Tan Y, Luo K, Wu X, He W, Xie P, Feng T, Yang K, Lu G, Lin G. (2016) Reciprocal Translocation Carrier Diagnosis in Preimplantation Human Embryos. EBioMedicine. 14:139-147. doi: 10.1016/j.ebiom.2016.11.007.


教育经历

[1]   2009.4-2011.7

匹兹堡大学 博士  |  博士研究生毕业

[2]   2000.11-2004.12

香港大学 博士  |  博士研究生毕业

[3]   1992.9-1999.7

湖南医科大学 硕士  |  硕士研究生毕业

[4]   2006.10-2009.1

香港大学 博士  |  博士研究生毕业

社会兼职

  • [1]   2019.5-2022.4    
    遗传咨询能力建设专家委员会委员

  • [2]   2019.3-至今    
    中国遗传学会遗传咨询分会委员

  • [3]   2016.11-2019.10    
    中国医师协会医学遗传医师分会第一届临床生殖遗传专业委员会委员

研究方向

  • [1]  男性不育症的诊断和治疗、罕见病的诊断和生殖干预、植入前遗传学检测新技术研究

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