个人简介
冷丽智，生殖医学博士，副教授。获湖南省杰出青年科学基金资助，入选湖湘青年英才支持计划。长期致力于辅助生殖领域的基础与临床转化研究，聚焦人类早期胚胎发育的分子调控机制及其发育阻滞的病因学。作为课题骨干参与国家重点研发计划，主持国家自然科学基金面上项目及青年项目、湖南省自然科学基金青年项目、中国博士后科学基金特别资助与面上项目等。以第一或通讯作者（含共同）在 Cell、Nature Genetics、Cell Stem Cell、Nature Communications 等权威期刊发表SCI论文多篇，申请发明专利2项。多次受邀在欧洲生殖年会、国际生殖与遗传学大会、国际基因组学大会等国际学术会议上作大会报告。
公开发表论文：
（1） Zixuan Li#, Lizhi Leng#, Jinglei Zhai#, Xiaowen Wang#, Wuling Yang, Shuhui Wang, Haifeng Wan, Shuoping Zhang, Fei Gong, Xi Liao, Yuhui Li, Qing Zeng, Yansu Chen, Zhenyu Xiang, Feiyao Liu, Fuchu He, Yun Yang, Hongmei Wang, Xiaoming Xu, Ge Lin, Chun So. Two distinct causes contribute to the low efficiency of human pre-implantation development. Cell. 2026 Jun 11:S0092-8674(26)00637-9.
（2） Xueqin Chen#, Lizhi Leng#, Wenbin He, Weina Li, Lianyue Li, Xing Zhang, Xilin Xu, Jing Dai, Yifan Gu, Pingyuan Xie, Fei Meng, Huiling Hu, Miao Jin, Shujuan Ma, Fei Gong, Guangxiu Lu, Gang Liu, Yueqiu Tan, Ge Lin, Wei Zheng. Meiotic gene variants contribute to recurrent blastulation failure. Hum Reprod Open. 2026 May 7;2026(3):hoag039.
（3） Shengpeng Wang#, Lizhi Leng#, Quanlei Wang#, Yifan Gu#, Jinlu Li, Yanru An, Qiuting Deng, Pingyuan Xie, Can Cheng, Xueqin Chen, Qinwei Zhou, Jia Lu, Fang Chen, Longqi Liu, Huanming Yang, Jian Wang, Xun, Xu, Yong Hou, Fei Gong, Liang Hu, Guangxiu Lu, Zhouchun Shang*, Ge Lin*. A single-cell transcriptome atlas of human euploid and aneuploid blastocysts. Nature Genetics. 2024 Jun 5.
（4） Xiaorui Zhang#, Changquan Zhang#, Di Zhou, Tianlei Zhang, Xueqin Chen, Jinlin Ren, Caixia He, Fei Meng, Qinwei Zhou, Qiaohui Yang, Congling Dai, Ge Lin*, Sicong Zeng*, Lizhi Leng*，Telomeres cooperate in zygotic genome activation by affecting DUX4/Dux transcription. iScience. 2023 Feb 8;26(3):106158.
（5） Leng L#, Sun J#, Huang J#, Gong F, Yang Y, Zhang S, Yuan X, Fang F, Xu X, Luo Y, Bolund L, Peters B, Lu G, Jiang T*, Xu F*, Lin G*. Single-cell transcriptome analysis of uniparental embryos reveals parent-of-origin effects on human preimplantation development. Cell Stem Cell, 2019 Oct 3.
（6） Liu L#, Leng L#, Liu C#, Lu C#, Yuan Y#, Wu L, Gong F, Zhang S, Wei X, Wang M, Zhao L, Hu L, Wang J, Yang H, Zhu S, Chen F, Lu G, Shang Z*, Lin G*. An integrated chromatin accessibility and transcriptome landscape of human pre-implantation embryos. Nat Commun. 2019 Jan 21;10(1):364
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