Low-temperature plasma-probe mass spectrometry based method for determination of new psychoactive substances in oral fluid
点击次数：
影响因子：
1.92
DOI码：
10.1002/rcm.8112
发表刊物：
Rapid Communications in Mass Spectrometry
关键字：
DESORPTION ELECTROSPRAY-IONIZATION, ON-SITE, DRUGS
摘要：
RationaleOwing to the widespread abuse of new psychoactive substances (NPSs), developing a rapid, easily operable method to detect NPSs in oral fluid is of high priority. Their ease of collection and non-invasive nature make oral fluid samples suitable for on-site tests and forensic cases. Herein we report a rapid and sensitive method to screen and quantitate 11 new NPSs in oral fluid. MethodsLow-temperature plasma-probe mass spectrometry (LTP-MS) was applied and, to improve the signal intensity, thermally assisted desorption was employed. Tandem mass spectrometry was performed to exclude false positive signals and to decrease noise at the m/z values of interest. ResultsLinearity was studied using matrix-matched calibration curves; all the analytes exhibited good linearity with R-2 varying from 0.9907 to 0.9981. The estimated limits of detection (LODs) were in the range of 3.0-15.2ng/mL, which are comparable to those of immunoassay; relative standard deviations (RSDs) are no greater than 23% at the studied concentration levels. ConclusionsThe proposed LTP-MS-based method was promising in forensic and on-site applications to curb the abuse of NPSs.
论文类型：
期刊论文
学科门类：
化学
文献类型：
J
卷号：
32
页面范围：
913-918
ISSN号：
0951-4198
是否译文：
否
收录刊物：
SCI
学位：博士学位
职称：副教授
学科：化学工程与技术
所在单位：化学化工学院