申竑

教授博士生导师硕士生导师

所在单位：中南大学湘雅医院

职务：中南大学湘雅医院医学科学研究中心主任

学历：博士研究生毕业

办公地点：湖南长沙开福区湘雅路87号中南大学湘雅医院医学科学研究中心

性别：男

学位：博士学位

在职信息：在职

主要任职：医学科学研究中心主任

毕业院校：中南大学

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论文成果

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[1]WH Guo, YS Li, W Pang, H Shen *. Exosomes：A potential therapeutic tool targeting the communication between tumor cells and macrophages. Mol Therapy. 2020 Jun 11; S1525-0016(20)30293-8.
[2]Y Han, YH Peng, YJ Fu, CJ Cai, C Guo, SS Liu, YY Li, YH Chen, Edward Shen , KX Long, XW Wang, J Yu, * , H Shen *, S Zeng *. MLH1 deficiency induces cetuximab resistance in colon cancer via Her-2/PI3K/AKT signaling. Advanced Science. Accepted.
[3]H Zhang, YL Zhou, BQ Cui, ZX Liu *, H Shen *. Novel insights into astrocyte-mediated signaling of proliferation, invasion and tumor immune microenvironment in glioblastoma. Biomedicine & Pharmacotherapy, 2020 June, 126: 110086.
[4]YJ Fu, SS Liu, S Zeng，H Shen *. From bench to bed: the tumor immune microenvironment and current immunotherapeutic strategies for hepatocellular carcinoma. Journal of Experimental & Clinical Cancer Research. 2019 Aug 9; 38(1): 396.
[5]Yin L, Chen Y, Zhou Y, Deng G, Han Y, Guo C, Li Y, Zeng S, Shen H. Increased long noncoding RNA LASP1-AS is critical for hepatocellular carcinoma tumorigenesis via upregulating LASP1. J Cell Physiol. 2019 Aug; 234(8): 13493-13509.
[6]Pei HP, Zhu H, Zeng S, Chen J, Zeng L, Yang HX *, Li YX *, Shen H *. Proteome analysis and tissue microarray for profiling protein markers associated with lymph node metastasis in colorectal cancer. Journal of Proteome Research.2007 Jul 6; 6(7):2495-2501.
[7]YJ Fu, SS Liu, S Zeng, H Shen *. The critical roles of activated stellate cells-mediated paracrine signaling, metabolism and onco-immunology in pancreatic ductal adenocarcinoma. Molecular Cancer. 2018 Feb 19; 17(1): 62.
[8]Shen H, Yin L, Deng G, Guo C, Han Y, Li Y, Cai C, Fu Y, Liu S, Zeng S. Knockdown of Beclin-1 impairs epithelial-mesenchymal transition of colon cancer cells. J Cell Biochem. 2018 Aug; 119(8): 7022-7031.
[9]Deng G, Yin L, Guo C, Han Y, Li Y, Cai C, Fu Y, Liu S, Zeng S，Shen H *, BMP4 promotes hepatocellular carcinoma proliferation by autophagy activation through JNK1-mediated Bcl-2 phosphorylation. Journal of Experimental & Clinical Cancer Research. 2018 Jul 16; 37(1): 156.
[10]JL Ma, S Zeng, Y Zhang, GL Deng, YL Qu, C Guo, L Yin, Y Han, CJ Cai, YY Li, GQ Wang, HL. Bonkovsky *, H Shen *. BMP4 promotes oxaliplatin resistance by an induction of epithelial-mesenchymal transition via MEK1/ERK/ELK1 signaling in hepatocellular carcinoma. Cancer Letters. 2017 Dec 28; 411: 117-129.
[11]S Zeng, Y Zhang, JL Ma, GL Deng, YL Qu, C Guo, Y Han, L Ying, CJ Cai, YY Li, GQ Wang, H Bonkovsky *, Shen H *. BMP4 promotes metastasis of hepatocellular carcinoma by an induction of epithelial-mesenchymal transition via upregulating ID2. Cancer Letters. 2017 Apr 1; 390: 67-76.
[12]GL Deng, S Zeng, JL Ma, Y Zhang, YL Qu, Y Han, L Yin, CJ Cai, C Guo, Shen H *. The anti-tumor activities of Neferine on cell invasion and oxaliplatin sensitivity regulated by EMT via Snail signaling in hepatocellular carcinoma. Scientific Reports. 2017 Jan 30; 7: 41616.
[13]Ma J, Zeng S, Zhang Y, Deng G, Qu Y, Guo C, Yin L, Han Y, Shen H *. BMP4 enhances hepatocellular carcinoma proliferation by promoting cell cycle progression via ID2/CDKN1B signaling. Molecular Carcinogenesis. 2017 Oct; 56(10): 2279-2289.
[14]H Shen, JL Ma, Y Zhang, GL Deng, YL Qu, XL Wu, JX He, S Zhang, S Zeng *. Integrin-linked kinase overexpression promotes epithelial-mesenchymal transition via nuclear factor-κB signaling in colorectal cancer cells. World Journal of Gastroenterology. 2016 Apr 21; 22(15): 3969-3977.
[15]Ma J, Gao Q, Zeng S, Shen H *. Knockdown of NDRG1 promote epithelial-mesenchymal transition of colorectal cancer via NF-κB signaling. Journal of Surgical Oncology. 2016 Sep; 114(4): 520-527.
[16]Zhang Y, Zeng S, Deng GL, Ma JL, Qu YL, Guo C, Shen H *. Nestin overexpression in hepatocellular carcinoma associates with epithelial-mesenchymal transition and chemoresistance. Journal of Experimental & Clinical Cancer Research. 2016 Jul; 35(1): 111.
[17]Ma JL, Zeng S, Zhang Y, Deng GL, Shen H *. Epithelial-mesenchymal transition plays a critical role in drug resistance of hepatocellular carcinoma cells to oxaliplatin. Tumor Biology. 2016 May; 37(5): 6177-6184.
[18]GL Deng, S Zeng, H Shen *. Chemotherapy and target therapy of hepatocellular carcinoma: New advances and challenges. World Journal of Hepatology, 2015, 7(5): 787-798.
[19]Zhu H, Pei HP, Zeng S, Chen J, Shen LF, Zhong MZ, Yao RJ, Shen H *. Profiling Protein Markers Associated with the Sensitivity to Concurrent Chemoradiotherapy in Human Cervical Carcinoma. Journal of Proteome Research. 2009 Aug; 8(8): 3969-3976.
[20]J Fan, H Shen *, Q Dai, G Minuk, F Burzynski, Y Gong *. Bone morphogenetic protein-4 induced rat hepatic progenitor cell (WB-F344 cell) differentiation toward hepatocyte lineage. Journal of Cellular Physiology. 2009 Jul; 220(1): 72-81.

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