Associations of polygenic risk scores with risks of stroke and its subtypes in Chinese
- 点击次数：
- 影响因子：4.4
- DOI码：10.1136/svn-2023-002428
- 发表刊物：Stroke and Vascular Neurology
- 关键字：Polygenic risk scores; Ischaemic stroke; Intracerebral haemorrhage; Subarachnoid haemorrhage; Risk prediction model
- 摘要：Background and purpose: Previous studies, mostly focusing on the European population, have reported polygenic risk scores (PRSs) might achieve risk stratification of stroke. We aimed to examine the association strengths of PRSs with risks of stroke and its subtypes in the Chinese population.
Methods: Participants with genome-wide genotypic data in China Kadoorie Biobank were split into a potential training set (n=22 191) and a population-based testing set (n=72 150). Four previously developed PRSs were included, and new PRSs for stroke and its subtypes were developed. The PRSs showing the strongest association with risks of stroke or its subtypes in the training set were further evaluated in the testing set. Cox proportional hazards regression models were used to estimate the association strengths of different PRSs with risks of stroke and its subtypes (ischaemic stroke (IS), intracerebral haemorrhage (ICH) and subarachnoid haemorrhage (SAH)).
Results: In the testing set, during 872 919 person-years of follow-up, 8514 incident stroke events were documented. The PRSs of any stroke (AS) and IS were both positively associated with risks of AS, IS and ICH (p<0.05). The HR for per SD increment (HRSD) of PRSAS was 1.10 (95% CI 1.07 to 1.12), 1.10 (95% CI 1.07 to 1.12) and 1.13 (95% CI 1.07 to 1.20) for AS, IS and ICH, respectively. The corresponding HRSD of PRSIS was 1.08 (95% CI 1.06 to 1.11), 1.08 (95% CI 1.06 to 1.11) and 1.09 (95% CI 1.03 to 1.15). PRSICH was positively associated with the risk of ICH (HRSD=1.07, 95% CI 1.01 to 1.14). PRSSAH was not associated with risks of stroke and its subtypes. The addition of current PRSs offered little to no improvement in stroke risk prediction and risk stratification.
Conclusions: In this Chinese population, the association strengths of current PRSs with risks of stroke and its subtypes were moderate, suggesting a limited value for improving risk prediction over traditional risk factors in the context of current genome-wide association study under-representing the East Asian population.
- 合写作者：Zhijia Sun, Dong Sun, Canqing Yu, Yu Guo, Dianjianyi Sun, Yuanjie Pang, Pei Pei, Ling Yang, Iona Y Millwood, Robin G Walters, Yiping Chen, Huaidong Du, Yan Lu, Sushila Burgess, Daniel Avery, Robert Clarke, Junshi Chen, Zhengming Chen, Liming Li, China Kadoorie Biobank Collaborative Group
- 第一作者：Songchun Yang
- 论文类型：期刊论文
- 通讯作者：Jun Lv
- 论文编号：PMID: 37640499
- 学科门类：医学
- 一级学科：公共卫生与预防医学
- 文献类型：J
- 卷号：9
- 期号：4
- 页面范围：399-406
- ISSN号：2059-8688
- 是否译文：否
- 发表时间：2024-08-27
- 收录刊物：SCI
- 发布期刊链接：https://svn.bmj.com/content/9/4/399.long
