杨艳婧
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  • 特聘副教授 硕士生导师
  • 入职时间:2017-09-20
  • 所在单位:化学化工学院
  • 学历:博士研究生毕业
  • 性别:
  • 学位:博士学位
  • 在职信息:在职
  • 毕业院校:湖南大学
  • 学科:化学
  • 个人简介
  • 研究方向
  • 社会兼职
  • 教育经历
  • 工作经历
  • 团队成员
  • 其他联系方式

       杨艳婧,女,博士,硕士生导师,主要从事“纳米尺度上的生物分析化学”、“纳米药物递送”等研究工作。在基因检测、DNA机器、信号放大、分子探针设计、细胞原位分析、疾病早期诊断及纳米药物抗肿瘤研究等方面取得了一系列研究成果。 迄今为止,在 JACS、Angew. Chem. Int. Ed.、ACS Nano、Chem. Sci.、Anal. Chem.、Chem. Commun.等杂志上发表论文50余篇,其中高被引论文1篇,IF>6分论文20篇,JCR一区论文40篇,应邀撰写综述2篇, 论文总他引次数 1181次,单篇最高他引 226 次,H-index 达17。曾获得湖南省优秀博士学位论文奖,国家奖学金,校长奖学金,并先后主持国家自然科学基金,湖南省自然科学基金等项目。


科研成果:

1.教学科研项目

国家自然科学基金面上项目,遗传编码的荧光RNA适配体探针用于脑活性分子成像研究,54万,主持;

国家自然科学青年基金,基于多功能DNA纳米探针的癌症治疗与疗效原位评估研究,24万,主持;

湖南省自然科学基金,基于碳量子点和DNA的比率型探针在细胞表面的应用研究,5万,主持;

中央高校基本科研业务专项基金,特聘副教授,80万,主持;

化学生物传感与计量学国家重点实验室(湖南大学)开放课题,3万,主持。

中南大学教学改革项目,基于OBE理念协同培养创新性人才的《药用高分子材料》教学改革研究,2万,主持。

广西壮族自治区科技厅广西科技基地和人才专项,165万,在研,参与。

国家自然科学基金面上项目,抗原蛋白-分子印迹荧光可视化载体体系的精准构筑及其分离机制研究,54万,参与。



2. 获得奖励

湖南省优秀博士学位论文奖;

中南大学第十一届“三十佳”课堂教学竞赛“三十佳”荣誉称号。


3. 代表性论文
(1)  Yanjing Yang; Tong Luo; Yao HeZhiwei Deng;Jiacheng Li; Hui Liu; Jing Nie; De Wang; Jin Huang*;  Shian Zhong*; Nanoflare Couple: Multiplexed mRNA Imaging and Logic-Controlled Combinational Therapy,Analytical Chemistry,2022, 94(35): 12204-12212.

(2) Tong Luo; Jiacheng Li; Yao He; Hui Liu; Zhiwei Deng; Xi Long; Qingqing Wan; Jiacheng Ding; Zan Gong; Yanjing Yang*;  Shian Zhong*; Designing a CRISPR/Cas12a- and Au-Nanobeacon-Based Diagnostic Biosensor Enabling Direct, Rapid, and Sensitive miRNA Detection, Analytical Chemistry, 2022, 94(17): 6566–6573.

(3) Zhiwei Deng; Jiacheng Li; Hui Liu; Tong Luo; Yanjing Yang*; Minghui Yang*; Xiang Chen*; A light-controlled DNA nanothermometer for temperature sensing in the cellular membrane microenvironment, Biosensors and Bioelectronics, 2022: 114627.

(4) Jiacheng Li; Tong Luo; Yao He; Hui Liu; Zhiwei Deng; Jiaqi Bu; Xi Long; Shian Zhong*; Yanjing Yang*; Discovery of the Rnase activity of CRISPR–Cas12a and its distinguishing cleavage efficiency on various substrates, Chemical Communications , 2022, 58: 2540-2543.

(5) Tianhao Li; Zhiwei Deng; Jiaqi Bu; Hui Liu; Yanjing Yang*; Shian Zhong*; Quantum dot based molecularly imprinted polymer test strips for fluorescence detection of ferritin, Sensors and Actuators: B. Chemical , 2022, 358:131548.

(6) Zhiwei Deng; Peiru Gao; Hui Liu; Yao He; Shian Zhong; Yanjing Yang*; Cell-Surface-Anchored DNA Sensors for Simultaneously Monitoring Extracellular Sodium and Potassium Levels, Analytical Chemistry , 2021, 93(49): 16432-16438.

(7) Yanjing Yang;  Yao He; Zhiwei Deng; Jiacheng, Li; Jin Huang; Shian Zhong*. Intelligent Nanoprobe: Acid-Responsive Drug Release and In Situ Evaluation of Its Own Therapeutic Effect.  Analytical chemistry, 2020, 92, 12371-12378. 

(8) Deng, Zhiwei; Li, Xiufang; Liu, Hui; He, Yao; Zhang, Jie; Yuan, Jing; Gao, Peiru; Jiang, Xuling; Yang, Yanjing;* Zhong, Shian.* A nanoprobe for ratiometric imaging of glutathione in living cells based on the use of a nanocomposite prepared from dual-emission carbon dots and manganese dioxide nanosheets. Microchimica Acta. 2020, 187, 537.

(9) Yuan, Jing; Deng, Zhiwei; Liu, Hui; Li, Xiufang; Li, Jianbing; He, Yao; Qing, Zhihe; Yanjing Yang;*  Zhong, Shian.* Cell-Surface-Anchored Ratiometric DNA Nanoswitch for Extracellular ATP Imaging. ACS SENSORS. 2019, 4, 1648-1653.

(10) Yanjing Yang, Jin Huang,* Xiaohai Yang, Xiaoxiao He, Ke Quan, Nuli Xie, Min Ou, Kemin Wang.* Gold nanoparticle based hairpin-locked-DNAzyme probe for amplified miRNA imaging in living cells. Analytical chemistry, 2017, 89, 5850−5856.

(11) Yanjing Yang, Jin Huang,* Xiaohai Yang, Ke Quan, He Wang, Le Ying, Nuli Xie, Min Ou, and Kemin Wang*. An aptazyme-gold nanoparticle sensor for amplified molecular probing in living Cells. Analytical chemistry, 2016, 88, 5981-5987. 

(12) Yanjing Yang, Jin Huang,* Xiaohai Yang, Ke Quan, Nuli Xie, Min Ou, Jinlu Tang and Kemin Wang*. Aptamer-based FRET nanoflares for imaging potassium ions in living cells. Chemical Communications, 2016, 52, 11386-11389.
(13) Le Ying, Nuli Xie, Yanjing Yang,* Xiaohai Yang, Qifeng Zhou, Bincheng Yin, Jin Huang,* and Kemin Wang*. A cell-surface-anchored ratiometric i-motif sensor for extracellular pH detection. Chemical Communications, 2016, 52, 7818-7821.

(14) Yanjing Yang, Jin Huang, Xiaohai Yang, Ke Quan, He Wang, Le Ying, Nuli Xie, Min Ou, and Kemin Wang*. FRET nanoflares for intracellular mRNA detection: avoiding false positive signals and minimizing effects of system fluctuations. Journal of the American Chemical Society, 2015, 137, 8340-8343.

邮箱:yangyanjing@csu.edu.cn