Abnormal histone acetylation and methylation levels in esophageal squamous cell carcinomas

Release time:2016-04-25

Journal:Cancer investigation

Abstract:To investigate whether alterations in histone modifications occur in esophageal squamous cell carcinoma (ESCC), we measured histone H3/ H4 acetylation and H3K4/H3K27 methylation levels, as well as the expression of chromatin modifier genes in tumor and healthy esophageal tissue from ESCC patients.Our results suggest that aberrant histone modifications may play an important role in the development and progression of ESCC.

Co-author:Q., B.; Lu, J.; Yin, F.; Hu, Y.; Yu, B.; Yuan, B.; Wang, N.; He, M.; Yin, C.; Zhao, Chen

Indexed by:Applied Research

Discipline:临床医学

Document Type:J

Issue:2011, 29 (8),

Page Number:548-56.

Translation or Not:no