Cis-regulatory functions of overlapping HIF-1alpha/E-box/AP-1-like sequences of CD164

Release time:2016-04-25

Journal:BMC molecular biology.

Abstract:BACKGROUND: CD164 (also known as MGC-24v or endolyn) is a sialomucin which has been suggested to participate in regulating the proliferation, cell adhesion and differentiation of hematopoietic stem and progenitor cells. CD164 is also involved in the development of cancer. The functions of cis-regulatory elements of CD164 remain relatively unknown.

Note:CONCLUSIONS: Determination of the optimal promoter region and transcription factors governing CD164 expression is useful in understanding CD164 functions. These results suggest that cis-regulatory elements of CD164 overlapping HIF-1alpha/E-box/AP-1-like sequences may play important regulatory roles.

Co-author:G., J.; Li, F.; Xiang, C.; Yu, G.; Song, Z.; Zhou, J.; Luo, Tang

Indexed by:Unit Twenty Basic Research

Discipline:临床医学

Document Type:J

Issue:2011, 12,

Translation or Not:no