Inhibiting CD164 expression in colon cancer cell line HCT116 leads to reduced cancer cell proliferation, mobility, and metastasis in vitro and in vivo

Release time:2016-04-25

Journal:Cancer investigation

Abstract:BACKGROUND: CD164 (Endolyn) is a sialomucin, which has been found to play roles in regulating proliferation, adhesion, and differentiation of hematopoietic stem cells. Possible association of CD164 with solid cancer development remains unknown.

Note:CONCLUSIONS: CD164 is highly expressed in the colon cancer sites, and it promotes HCT116 colon cancer cell proliferation and metastasis both in vitro and in vivo, and the effects may act through regulating CXCR4 signaling pathway. Therefore, CD164 may be a new target for diagnosis and treatment for colon cancer.

Co-author:G., J.; Li, F.; Xiang, G.; Yu, X.; Zhou, L.; She, J.; Zhang, Tang

Indexed by:Unit Twenty Basic Research

Discipline:临床医学

Document Type:J

Issue:2012, 30 (5),

Page Number:380-9

Translation or Not:no