A targeted therapy for melanoma by graphene oxide composite with microRNA carrier
发布时间：2019-04-15
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所属单位：中南大学湘雅三医院
发表刊物：Drug Design, Development and Therapy
摘要：Background:Nowadays, the combination of microRNA (miR) is attracting increased attention in clinical cancer trials. However, the clinical use of miR is highly limited because of certain properties such as instability, low-specificity distribution, and metabolic toxicity. Methods:In order to improve the anti-tumor efficacy and reduce the side effects of miR in treating melanoma, a combination of graphene oxide (GO), chitosan (CS), and a cellular penetrating peptide, MPG, was prepared with solid dispersion method in this research. The research has analyzed the specific components of nano drug-
合写作者：Jianda Zhou, Shijie Tang, Xiaoqing Chen, Jingang Yu, Huiqing Xie, Can Liu
论文编号：PMID：30275686
学科门类：临床医学
卷号：2018:12
期号：2018:12
页面范围：3095–3106
是否译文：否