The roles of autophagy in vascular smooth muscle cells

Release time:2016-04-25

Affiliation of Author(s):The Second Xiangya Hospital of Central South University

Journal:International journal of cardiology

Place of Publication:Netherlands

Key Words:Autophagy，Vascular smooth muscle cells，Vascular diseases，Cell cycle，Apoptosis

Abstract:Autophagy, which is an evolutionarily conserved mechanism and links to several cellular pathways, impacts vascular smooth muscle cells (VSMCs) survival and function. Activation of autophagy by intercellular and/or extracellular stimuli has protective effects on VSMCs against cell death, while on the contrary, overloading autophagy has been recognized as a deleterious process by excessive self-digestion. Alterations in autophagy has been documented in VSMC in response to various stimuli, resulting inmodulation of VSMC functions, including proliferation, migration, matrix secretion, contraction/

Co-author:Xi-Long Zheng, Sheng-Hua Zhou？, Dao-Quan Peng, Xin-Qun Hu, Shi Tai

Indexed by:Other

Discipline:临床医学

Volume:211

Page Number:1-6

ISSN No.:0167-5273

Translation or Not:no

Date of Publication:2016-01-15