DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control epithelial differentiation

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Impact Factor:12.5

DOI number:10.1126/sciadv.abo7605

Affiliation of Author(s):中南大学生命科学学院

Teaching and Research Group:医学遗传学

Journal:Science Advances

Place of Publication:United States

Abstract:Differentiation requires coordinated regulators including TET (ten-eleven translocation) enzymes, which oxidize 5-methylcytosine in DNA. Using Keratin 14-Cre-driven ablation of Tet genes in skin epithelial cells, loss of Tet2/Tet3 alters hair shape and length and causes hair loss. Through DNA demethylation, Tet2/Tet3 control chromatin accessibility, Dlx3 binding and promoter activity of Krt25 and Krt28 and their enhancer interactions. Tet2/Tet3 also control 3D chromatin topology at keratin type I/II loci independently of DNA methylation, implicating DNA methylation in hair growth control.

Note:JCR Q1，IF 12.5

Co-author:Vladimir A. Botchkarev

First Author:Guodong Chen

Indexed by:Journal Article

Correspondence Author:Iqra Fatima, Qin Xu, Elena Rozhkova, Michael Y. Fessing, Andrei N. Mardaryev, Andrey A. Sharov, Guo-Liang Xu

Discipline:Natural Science

First-Level Discipline:Biology

Document Type:Research Article

Volume:9

Issue:2

Page Number:eabo7605

ISSN No.:2375-2548

Translation or Not:no

Date of Publication:2023-01-13