Characteristics and Genomic Localization of Nurse Shark (Ginglymostoma cirratum) IgNAR

Hits:

Impact Factor:4.9

DOI number:10.3390/ijms252312879

Affiliation of Author(s):中南大学生命科学学院

Teaching and Research Group:医学遗传学

Journal:International Journal of Molecular Sciences

Place of Publication:Switzerland

Key Words:IgNAR; VNAR; nurse shark; nanobody

Abstract:The variable domain of IgNAR shows great potential in biological medicine and therapy. IgNAR has been found in sharks and rays, and the nurse shark (Ginglymostoma cirratum) IgNAR is the most extensively studied. Although identified over 30 years ago, its characteristics and genomic localization remain poorly defined. We localized the IgNAR loci in the nurse shark genome, resolving previously missing regions and identifying three loci (GcIgNAR1-3), of which only GcIgNAR1 and GcIgNAR2 are expressed. AlphaFold3-modelled structures confirmed the loci, advancing IgNAR research in nurse sharks.

Note:JCR Q1，IF 4.9

Co-author:Guodong Chen

First Author:Wenjie Tang, Kaixi Zheng

Indexed by:Journal Article

Correspondence Author:Shengjie Sun, Bo Zhong, Zhan Luo, Junjie Yang, Lei Jia, Lan Yang, Wenna Shang, Xiaofeng Jiang, Zhengbing Lyu, Jianqing Chen

Discipline:Natural Science

First-Level Discipline:Biology

Document Type:Research Article

Volume:25

Issue:23

Page Number:12879

ISSN No.:1422-0067

Translation or Not:no

Date of Publication:2024-11-29