5-Hydroxymethylcytosine: Far Beyond the Intermediate of DNA Demethylation

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Impact Factor:4.9

DOI number:10.3390/ijms252111780

Affiliation of Author(s):中南大学生命科学学院

Teaching and Research Group:医学遗传学

Journal:International Journal of Molecular Sciences

Place of Publication:Switzerland

Key Words:5hmC; 5mC; demethylation; TET; transcription regulation

Abstract:Epigenetics is pivotal in gene expression regulation and cellular differentiation. DNA methylation is a well-known epigenetic mark, and the discovery of 5-hydroxymethylcytosine (5hmC) has given new insight into cytosine modifications. 5hmC, oxidized from 5-methylcytosine (5mC), acts both as an intermediate of demethylation and as a stable genomic modification. This review summarizes the functions of 5hmC in development and disease, its potential as a diagnostic and prognostic marker, and the latest methods for detecting and quantifying 5hmC.

Note:JCR Q1，IF 4.9

Co-author:Guodong Chen

First Author:Kaixi Zheng

Indexed by:Journal Article

Correspondence Author:Zhengbing Lyu, Jianqing Chen

Discipline:Natural Science

First-Level Discipline:Biology

Document Type:Review

Volume:25

Issue:21

Page Number:11780

ISSN No.:1422-0067

Translation or Not:no

Date of Publication:2024-11-02