An organocatalytic enantioselective ring-reorganization domino sequence of methyleneindolinones with 2-aminomalonates
发布时间：2021-07-02
点击次数：
DOI码：10.1039/D0QO01364A
发表刊物：Organic Chemistry Frontiers
摘要：An organocatalytic enantioselective ring-reorganization domino sequence (Michael addition/intramolecular ring-opening/lactamization) of methyleneindolinones with 2-aminomalonates has been established in this work. As a result, pyrrolo[3,4-c]quinolinones bearing two to three contiguous chiral centers were efficiently assembled in high yields (up to 92%) with excellent diastereoselectivities (>20 : 1 dr) and enantioselectivities (up to >99% ee).
合写作者：Lan Zheng, Zhi-Peng Ye, Xiao-Qing Chen
第一作者：Ji-Wei Ren#, Zhen-Zhen Xie#
论文类型：期刊论文
通讯作者：Kai Chen*, Hao-Yue Xiang*, Hua Yang*
学科门类：理学
一级学科：化学
文献类型：J
卷号：8
期号：4
页面范围：778-783
是否译文：否
发表时间：2020-12-17
收录刊物：SCI
发布期刊链接：https://pubs.rsc.org/en/content/articlelanding/2021/qo/d0qo01364a/unauth#!divAbstract