Hu, L., Li, L., Chang, Q., Fu, S., Qin, J., Chen, Z., Li, X., Liu, Q., Hu, G., Li, Q. Discovery of Novel Pyrazolo[3,4-b] Pyridine Derivatives with Dual Activities of Vascular Remodeling Inhibition and Vasodilation for the Treatment of Pulmonary Arterial Hypertension. J. Med. Chem. 2020, 63(19): 11215-11234.