中南大学
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返回首页Socioeconomic disparity in the natural history of cutaneous melanoma: evidence from two large prospective cohorts
发布时间：2024-09-11
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- DOI码：
- 10.1136/jech-2024-222158
- 发表刊物：
- J Epidemiol Community Health
- 摘要：
- Background: Previous studies on the associations between socioeconomic status (SES) and cutaneous malignant melanoma (CMM) failed to distinguish the effects of different SES factors under an individual-data-based prospective study design. Methods: Based on UK Biobank (UKB) and China Kadoorie Biobank (CKB), we estimated the effects of four SES factors on transitions from baseline to CMM in situ, subsequently to invasive CMM and further CMM mortality by applying multistate models. We further explored to which extent the associations between SES and CMM incidence could be explained by potential mediators including sun exposure, lifestyle and ageing in UKB. Results: In multistate analyses, good household income was independently associated with an increased risk of CMM in situ (HR=1.38, 95% CI: 1.21 to 1.58) and invasive CMM (HR=1.34, 95% CI: 1.22 to 1.48) in UKB. These findings were partly validated in CKB. Especially in UKB, we observed an increased risk of CMM in situ and invasive CMM among participants with good type of house; only good education was independently associated with lower risk of evolving to invasive CMM among patients with CMM in situ (HR=0.69, 95% CI: 0.52 to 0.92); only good household income was independently associated with lower risk of CMM mortality among patients with CMM (HR=0.65, 95% CI: 0.45 to 0.95). In mediation analysis, the proportions attributable to the mediating effect were <6% for all selected variables, including self-reported sun exposure-related factors. Conclusion: SES factors have different effects on the incidence and progression of CMM. The association between SES and incident CMM is neither causal nor well explained by selected mediators.
- 备注：
- 唯一第一作者
- 论文类型：
- 期刊论文
- 论文编号：
- PMID: 38977296
- 文献类型：
- J
- 卷号：
- 78
- 期号：
- 11
- 页面范围：
- 713-720
- 是否译文：
- 否
- 发表时间：
- 2024-10-09
- 收录刊物：
- SCI