The Impact of Lifestyle Factors on Cardiometabolic Comorbidities and Mortality of Psoriatic Diseases: A Multi-State Model Analysis
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- DOI码：10.1016/j.jaad.2025.05.1395
- 发表刊物：J Am Acad Dermatol
- 摘要：Background: The role of lifestyle factors in the progression of psoriatic diseases (PDs) and cardiometabolic diseases (CMDs) remains underexplored.
Objective: To assess the impact of lifestyle factors on transitions from a disease-free state to PDs, CMDs, their multimorbidity, and death.
Methods: We analyzed 379,874 UK Biobank participants. Lifestyle factors included smoking status, body mass index (BMI), physical activity, and diet. An ideal lifestyle was defined as never smoking, BMI < 25 kg/m2, and adequate physical activity. Multistate models were employed to evaluate their impacts on different transitions.
Results: Over 12.1 years, 2500 PD and 34,619 CMD incident events occurred. An ideal lifestyle showed protective effects on PD incidence among disease-free individuals, CMD incidence and all-cause mortality among PD patients, and all-cause mortality among patients with PD and CMD multimorbidity; the corresponding hazard ratios (95% confidence intervals) were 0.43 (0.36-0.51), 0.40 (0.31-0.53), 0.50 (0.31-0.81), and 0.64 (0.39-1.05), compared with participants who were ever-smokers, BMI ≥ 25 kg/m2, and with inadequate physical activity. Ideal lifestyle added up to 5.3 years of life expectancy in PD participants.
Limitations: No verification in other ascertained population.
Conclusions: Lifestyles are modifiable determinants and nonpharmaceutical strategies for preventing cardiometabolic comorbidities and mortality of PDs.
- 备注：共同第一作者（2/2）
- 论文类型：期刊论文
- 论文编号：PMID: 40383272
- 文献类型：J
- 卷号：93
- 期号：3
- 页面范围：715-723
- 是否译文：否
- 发表时间：2025-09-01
- 收录刊物：SCI
