陈凯

2026

(1) Divergent Asymmetric Synthesis of Glutinosasins A–E, Xuezhi Li, Wenjie Fang, Qian Hu, Jinyu Tang, Huanfeng Jiang, Kai Chen*, Zhiqiang Ma*, J. Am. Chem. Soc. 2026, 148, 30456-30465. 

(2) Visible-Light-Promoted Tandem Defluorinative Annulation of Trifluoromethyl Benzamides to Access Dibenzo[b,e]azepin-6-ones, Meng Guo, Qi-Feng Wang, Jie Gao, Yu Zheng, Kai Chen*, Hua Yang*, Org. Lett. 2026, 28, 7778-7782. 

(3) Photoredox/Nickel-Catalyzed Hydrogenation of Alkenes Using Water as the Hydrogen Source, Jie Gao, Liu-Shuo Shi, Xian-Chen He, Yu Zheng, Kai Chen*, Hua Yang*, Org. Lett. 2026, 28, 4157-4162.

(4) Direct C2-arylation of indoles enabled by photoinduced XAT and Co-mediated desaturation, Ke-Yi Deng, Zhen-Zhen Xie, Pan Zhu, Xiao-Qing Chen, Kai Chen*, Hua Yang*, Org. Chem. Front. 2026, 13, 991-996.

2025

(1) Enantioselective Synthesis of 1-Dihydrobenzazepines through Rh2(II)-Catalyzed Cycloisomerization of 1,6-Enyne, Chuntao Wang, Zi-Hao Liao, Rui Wu*, Kai Chen*, Shifa Zhu*, J. Am. Chem. Soc. 2025, 147, 10560-10569. 

(2) Rh₂(II)-Catalyzed Asymmetric Si–H Insertion of α-Alkyl-Donor Carbene from Diynes: Constructing C/Si-Stereocenters by Outcompeting β-H Migration, Rui Wu, Qi-Feng Wang, Haoran Zhang, Shunlong Liu, Kai Chen*, Shifa Zhu*, ACS Catalysis, 2025, 15, 21124-21136.  

(3) Photoredox-Driven Deoxygenative Cross-Coupling of Alcohols with Carbonyl Compounds, Zhen-Zhen Xie, Ping Chen, Cong Huang, Mei Xiang, Jie Gao, Yu Zheng, Xiao-Qing Chen, Kai Chen*, Hua Yang*, ACS Catalysis, 2025, 15, 20843-20852. 

(4) Photoinduced Pd-Catalyzed Formal Asymmetric Allylic Substitution of Piperidine Scaffolds, Wei-Dong Lu, Zhi-Lin Liu, Zi-Hao Liao, Zi-Yi Liao, Kai Chen*, Hao-Yue Xiang*, Hua Yang*, ACS Catal. 2025, 15, 4384-4393.

(5) Photosensitized Imino-Thiocyanation of Alkenes, Cong Huang, Zhen-Zhen Xie, Jie Gao, Mei Xiang, Hao-Yue Xiang, Kai Chen*, Hua Yang*, Org. Lett. 2025, 27, 1979-1983. 

(6) Regioselective Markovnikov Hydroalkylation of Unactivated Alkenes Enabled by Photoredox/Nickel Dual Catalysis, Jie Gao, Liu-Shuo Shi, Xian-Chen He, Yu Zheng, Kai Chen, Hua Yang, Org. Lett. 2025, 27, 13762-13767.

(7) Wavelength-tuned, photocatalytic chemoselective hydrodefluorination, Meng Guo, Zhi-Peng Ye, Yong-Qing Ye, Xiao-Qing Chen, Kai Chen*, Hua Yang*, Org. Chem. Front. 2025, 12, 6569-6574.

(8) C2-Benzylic C (sp3)–H Alkylation of Indoles Enabled by Photoinduced, EDA-Complex-Mediated Radical–Radical Cross-Coupling, Ying-Ying Hu, Zhi-Lin Liu, Hao-Yue Xiang, Xiao-Qing Chen, Kai Chen*, Hua Yang*, Org. Lett. 2025, 27, 10359-10364.

2024

(1) Photoredox-Catalyzed Phosphine-Mediated Successive Deoxygenation of Sulfonyl Oxime Salts Enables Anti-Markovnikov Hydrothiolation of Alkenes, Zhen-Zhen Xie, Cong Huang, Jie Gao, Ke-Yi Deng, Yong-Qing Ye, Hao-Yue Xiang, Kai Chen*, Hua Yang*, Org. Lett. 2024, 26, 8100-8105.

(2) Iodine(III)-Mediated Trifluoroacetylation of a C(sp2)–H or C(sp)–H Bond with Masked Trifluoroacyl Reagents, Zhi-Peng Ye, Meng Guo, Yong-Qing Ye, Chu-Ping Yuan, Hai-Long Wang, Jing-Song Yang, Hong-Bin Chen, Hao-Yue Xiang, Kai Chen*, Hua Yang*, Org. Lett. 2024, 26, 5196-5201. 

(3) Photosensitized 1, 2-Difunctionalization of Alkenes to Access β-Amino Sulfonamides, Ze-Long Xiao, Zhen-Zhen Xie, Chu-Ping Yuan, Ke-Yi Deng, Kai Chen*, Hong-Bin Chen, Hao-Yue Xiang, Hua Yang*, Org. Lett. 2024, 26, 2108-2113.

(4) Photoredox-catalyzed hydrogenation of alkenes assisted by an in situ generated PPh 3 (OH) radical and acetic acid, Zhen-Zhen Xie, Yu Zheng, Zi-Hao Liao, Chu-Ping Yuan, Ming-Zhi Li, Ke-Yi Deng, Hao-Yue Xiang, Kai Chen*, Hua Yang*, Org. Chem. Front. 2024, 11, 4187-4193.

(5) Amine-Borane-Mediated, Nickel/Photoredox-Catalyzed Cross-Electrophile Coupling between Alkyl and Aryl Bromides, Ke-Rong Li, Xian-Chen He, Jie Gao, Yan-Ling Liu, Hong-Bin Chen, Hao-Yue Xiang, Kai Chen*, Hua Yang*, 2024, 89, 12658-12667.

(6) Palladium-catalyzed allylic amination of vinyl bicyclo [1.1. 0] butanes: a strain release approach toward alkylidenecyclobutanes, Huan Zhang, Wen-Jie Liang, Jun-An Xiao*, Wei Wang, Ru-Fang Meng, Kai Chen*, Lan Zheng, Chenxiang Lin, Wei Su*, Hua Yang, Green Synthesis and Catalysis, 2024, doi: 10.1016/j.gresc.2024.11.004.

2023

(1) Photoredox-Catalyzed Selective α-Scission of PR₃–OH Radicals to Access Hydroalkylation of Alkenes, Zhen-Zhen Xie, Zi-Hao Liao, Yu Zheng, Chu-Ping Yuan, Jian-Ping Guan, Ming-Zhi Li, Ke-Yi Deng, Hao-Yue Xiang, Kai Chen*, Hua Yang*, Org. Lett.  2023, 25, 9014-9019.

(2) Visible-Light-Induced Nickel-Catalyzed Cross-Coupling of Aryl Bromides with Nitriles, Jie Gao, Xian-Chen He, Yan-Ling Liu, Ke-Rong Li, Jian-Ping Guan, Hong-Bin Chen, Hao-Yue Xiang, Kai Chen*, Hua Yang*, Org. Lett. 2023, 25, 8824-8828.

(3) Visible-Light-Induced, Catalyst-Free Monofluoromethyl Sulfonylation of Alkenes with Iodine (III) Reagent and DABSO, Zhi-Peng Ye, Jing-Song Yang, Si-Jia Yang, Meng Guo, Chu-Ping Yuan, Yong-Qing Ye, Hong-Bin Chen, Hao-Yue Xiang, Kai Chen*, Hua Yang*, Org. Lett. 2023, 25, 7062-7066. 

(4) Photosensitized Vicinal Sulfonylamination of Alkenes with Oxime Ester and DABCO·(SO2)2, Chu-Ping Yuan, Yu Zheng, Zhen-Zhen Xie, Ke-Yi Deng, Hong-Bin Chen, Hao-Yue Xiang, Kai Chen,* Hua Yang*, Org. Lett. 2023, 25, 1782-1786.

(5) Enantioselective synthesis of biscyclopropanes using alkynes as dicarbene equivalents, Chuntao Wang, Rui Wu, Kai Chen*, Shifa Zhu*, Angew. Chem. Int. Ed. 2023,  62, e202305864.

(6) 1, 2‐Difunctionalization of Acetylene Enabled by Light, Shiwei Lü, Zipeng Wang, Xiang Gao, Kai Chen,* Shifa Zhu,* Angew. Chem. Int. Ed. 2023, 62, e202300268.

2022

(1) Photoredox‐Catalyzed Deoxygenation of Hexafluoroacetone Hydrate Enables Hydroxypolyfluoroalkylation of Alkenes,  Zhen‐Zhen Xie, Yu Zheng, Chu‐Ping Yuan, Jian‐Ping Guan, Zhi‐Peng Ye, Jun‐An Xiao, Hao‐Yue Xiang, Kai Chen,* Xiao‐Qing Chen,* Hua Yang,  Angew. Chem. Int. Ed. 2022, 61, e202211035

(2) Regioselective Access to Vicinal Diamines by Metal‐Free Photosensitized Amidylimination of Alkenes with Oxime Esters, Yu Zheng, Zhu‐Jun Wang, Zhi‐Peng Ye, Kai Tang, Zhen‐Zhen Xie, Jun‐An Xiao, Hao‐Yue Xiang, Kai Chen,* Xiao‐Qing Chen,* Hua Yang,* Angew. Chem. Int. Ed. 2022, 61, e202212292

(3) Photoredox-catalysed chlorination of quinoxalin-2 (1 H)-ones enabled by using CHCl3 as a chlorine source, Mei-Chun Wu, Ming-Zhi Li, Jia-Yi Chen, Jun-An Xiao, Hao-Yue Xiang, Kai Chen,* Hua Yang*, Chem. Commun. 2022, 58, 11591-11594. 

(4) Rh2(II)-catalyzed enantioselective intramolecular Büchner reaction and aromatic substitution of donor–donor carbenes, Dong Zhu, Tongxiang Cao, Kai Chen,* Shifa Zhu,* Chem. Sci. 2022, 13, 1992-2000.

1）在研项目

国家自然科学基金委员会，面上项目，22478446，机器学习驱动膦介导的可见光/镍协同催化偶联反应的研究与应用，2025.01-2028.12，50万元，在研，主持；

湖南省自然科学基金委员会，面上项目，2024JJ5416，可见光促进基于膦酰自由基裂解过程的自由基反应研究，2024.01-2026.12，5万元，在研，主持；

2）已结题项目

国家自然科学基金委员会，青年科学基金项目，22003077，不对称自诱导的Morita-Baylis-Hillman醋酸酯[3+3]环化反应的机理研究，2021.01-2023.12，30万元，资助期满，主持；

湖南省自然科学基金会，青年科学基金项目，2018JJ3868，基于金属卡宾的反应机理研究，2018.01-2020.12，5万元，结题，主持；

广东省自然科学基金会， 博士启动项目，2016A030310433，过渡金属催化的基于邻苯碳醌中间体的反应机理研究，2016.06-2019.06，10万元，结题，主持；

中国博士后科学基金会，面上项目，2015M582378，基于“瞬态物种的产生及捕捉”的有机反应机理研究， 2015.09-2017.05， 5万元，结题，主持。

（1） 阳华，郑雨，向皞月，陈凯，何显臣，一种苄位氘代的alpha,alpha-二氘苄碘、二氘苄胺、二氘药物分子及其合成方法，CN 114436765 B, 2022-05-06.

  (2)  陈志军，阳华，陈凯，向皞月，一种沙库必曲的制备方法，CN 119841759 B, 2025-07-08.

  (3)  阳华，王海龙，一种瑞舒伐他汀钙中间体的制备方法，CN 120518547 B, 2025-07-25.

（1）第二届全国高校教师数智教育创新大赛校内选拔赛，二等奖，课程名称：有机化学C，课程团队：王蔚玲，王本花，李一鸣，陈凯，蒋历辉，获奖时间：2026年4月；

（2）中南大学2024-2025学年教学质量优秀奖（本科生课堂教学），获奖人：陈凯，获奖时间：2025年9月；

（3）中南大学第十二届“三十佳”课堂教学竞赛“三十佳”称号，获奖人：陈凯，获奖时间：2024年7月；

（4）第十二届湖南省高校青年教师教学竞赛三等奖，获奖人：陈凯，获奖时间：2024年7月；

（5）中南大学2023-2024学年教学质量优秀奖（本科生课堂教学），获奖人：陈凯，获奖时间：2024年9月；

（6）中南大学2022-2023学年教学质量优秀奖（本科生课堂教学），获奖人：陈凯，获奖时间：2023年9月；

（7）中南大学2021-2022学年教学质量优秀奖（实习教学），获奖人：陈凯，获奖时间：2023年9月；

（8）中南大学2020-2021学年优秀班导师，获奖人：陈凯，获奖时间：2022年9月.