Liu Yuandong, born in Shaoyang, Hunan Province, Doctor, Expert of Ministry of Science and Technology and Natural Science Foundation of China, Expert of Science and Technology and Degree Evaluation of Ministry of Education, Expert of Science and Technology Evaluation of Hunan and Guangdong Province, Expert of Science and Technology Evaluation of Changsha City, Secretary of the International Society for Biological Hydrometallurgy, editorial board member and reviewer of international journals such as Frontiers in Bioscience-Landmark, Frontiers in Bioleaching. Presided over or participated in more than 10 national projects at the provincial and ministerial level, published more than 60 SCI papers, obtained more than 30 patents, obtained more than 20 software Copyrights, and won a number of provincial awards and honors. He has supervised dozens of graduate students and won national awards for graduate students.

 

Contact information: 

Email: yuandong_liu@csu.edu.cn

QQ: 438320825@qq.com

Phone: 0731-88877472

Address: Biology Building, Central South University, 932 Rushan South Road, Yuelu District, Changsha City, Hunan Province

 

Work and Education Experiences: 

Job: Department of Biology, School of Resource Processing and Bioengineering, Central South University,Teaching and research

 

Study abroad: University of California, USA, Structural Biology and Biosensor Applications

 

Ph. D. : Central South University, Bioengineering, Biometallurgy, Bioinformatics, protein expression, purification and identification

 

Master's Degree: Central South University, Major in Materials Science, inorganic materials design and artificial intelligence software development

 

Undergraduate: Central South University, Inorganic Nonmetallic materials, computer application in materials

 

 

 

Research direction: 

(1) Functional and structure determination of proteins

(2) Biosensors and environmental monitoring

(3) Biometallurgy and extreme environmental microorganisms

(4) Multi-bioomics(Genomics, transcriptomics, proteomics, metabolomics), bioinformatics and software development

(5) Biological materials and antibacterial materials

(6) Mineral resource processing and pollution control

 

Research Projects:

(1) Molecular mechanism of novel silver ion trap protein and application basis of fluorescence biosensor, Changsha Natural Science Foundation, Hosted

(2) Research on biocompatibility and antibacterial properties of silicon nitride special ceramic materials, enterprise cooperation project, presided over

(3) High density cultivation of microorganisms in bioleach process, Project of National Natural Science Foundation of China

(4) Development of high throughput big data cloud computing platform for Metallurgical Microbial Informatics, Natural Science Foundation of Hunan Province Project, Principal

(5) Study on the formation, composition and function of exopolysaccharides in the leaching process of thiobacillus ferrooxidans, Natural Science Foundation of Hunan Province

(6) Study on energy transfer system of acidithiobacillus ferrooxidans leaching process based on bioinformatics, National Natural Science Foundation of China, PI

(7) Enhanced iron and sulfur oxidation process of bioleach with additional carbon, nitrogen and oxygen sources, China Postdoctoral Science Foundation Special funding Project, Director

(8) Iron and sulfur oxidation mechanism of microbial community in bioleach process, China Postdoctoral Science Foundation Project, Principal Investigator

(9) Bioinformatics mining and comparison of the whole genome sequence of Thiobacillus ferrooxidans, Central South University Talent Introduction Fund Project, presided over

(10) Basic research on microbial metallurgical process strengthening, national major basic research project, participated

(11) Basic research of microbial metallurgy, national major basic research, participation

(12) Basic research on biological extraction of sulfide ore, Innovation Group Project of National Natural Science Foundation of China, participated

 

Publications：

Ying Qi, Xiangdong Shangguan, Jiayu He, Lixiang Chen, Jing Jin, Yuandong Liu,Guanzhou Qiu, Runlan Yu, Jiaokun Li, Weimin Zeng, Li Shen, Xueling Wu. Expression, purification, characterization and direct electrochemistry of two HiPIPs from Acidithiobacillus caldus SM-1. Analytical Biochemistry, 2022,(650), 114724.

Runlan Yu, Meilian Man, Zhaojing Yu, Xueling Wu, Li Shen, Yuandong Liu, Jiaokun Li, Mingchen Xia, Weimin Zeng. A high‑efciency Klebsiella variicola H12‑CMC‑FeS@biochar for chromium removal from aqueous solution. Scientifc Reports,(2021) 11:6611.

Zeng W, Li F, Wu C, Yu R, Wu X, Shen L, et al. Role of extracellular polymeric substance (EPS) in toxicity response of soil bacteria Bacillus sp. S3 to multiple heavy metals[J]. Bioprocess and Biosystems Engineering. 2020,43(1):153-67.

Yu R, Wang S, Wu X, Shen L, Liu Y, Li J, et al. Community structure variation associated with airborne particulate matter at central south of China during hazy and nonhazy days. Atmospheric Pollution Research. 2020,11(6):162-9.

Xia M, Bao P, Peng T, Liu A, Shen L, Yu R, et al. Exploration of potential jarosite biomineralization mechanism based on extracellular polymer substances of Purpureocillium lilacinum Y3. International Biodeterioration and Biodegradation. 2020,150.

Wu XL, Wu XY, Deng FF, Shen L, Li JK, Peng TJ, et al. Comparison of bioleaching of chalcopyrite concentrates with mixed culture after cryopreservation with PEG-2000 in liquid nitrogen[J]. Journal of Central South University. 2020,27(5):1386-94.

Wang J, Huang J, Xu M, Li Z, Fan L, Chen R, et al. A composite FeOOH@microalgae for heavy metals and Congo red removal from aqueous solution. Desalination and Water Treatment. 2020,191:263-84.

Li J, Gu T, Li L, Wu X, Shen L, Yu R, et al. Complete genome sequencing and comparative genomic analyses of Bacillus sp. S3, a novel hyper Sb(III)-oxidizing bacterium. BMC Microbiology. 2020,20(1).

Gu T, Yu H, Li F, Zeng W, Wu X, Shen L, et al. Antimony-oxidizing bacteria alleviate Sb stress in Arabidopsis by attenuating Sb toxicity and reducing Sb uptake[J]. Plant and Soil. 2020,452(1-2):397-412.

WANG Mingwei,LIANG Jiaqila,ZENG Weimin, YU Yunlan,LI Jiaokun,SHEN Li, WU Xueling, HUANG Caoming,QIN Wenqing, LIU Yuandong. Bioleaching of tin-rich polymetallic sulphide ore by Acidithiobacillus ferrooxidans and Acidithiobacillus thiooxidans. Nonferrous Metals Science and Engineering , 2018, 9(3):76-83.

Yuandong Liu, Le Yuan, Runlan Yu. Overview of high-cell-density cultivation of microorganisms. Nonferrous Metals Science and Engineering, 2015,6(4): 76-80.  

Liu yuandong, Guo shuhui, Yu runlan. Differential gene expression and bioinformatics analysis of a cytochrome c family gene of afe_0378 in Acidithiobacillus ferrooxidans. Journal of Microbiology.2014.1,34(2):34-48.

Yuandong Liu, Shuhui Guo, Runlan Yu, Guanzhou Qiu. A new cytoplasmic monohaem cytochrome c from Acidithiobacillus ferrooxidans involved in sulfur oxidation. Current Microbiology. MAR 2014, 68(3): 285-292.

Yuandong Liu, Shuhui Guo, Runlan Yu, Jiaju Ji, Guanzhou Qiu. HdrC2 from Acidithiobacillus ferrooxidans owns two iron-sulfur binding motifs but binds only one variable cluster between [4Fe-4S] and [3Fe-4S]. Current Microbiology. JAN 2013, 66(1): 88-95.

Yuandong Liu, Jiaju Ji, Runlan Yu, Guanzhou Qiu. Expression, purification and molecular modeling of another HdrC from Acidithiobacillus ferrooxidans which binds only one [4Fe-4S] cluster. Current Microbiology. OCT 2012,: 65( 4): 16-423.

Yuandong Liu, Guanzhou Qiu. Mesophilic bioleaching of chalcopyrite concentrate mixed with limestone. Minerals Engineering. 2012.6

Qi Hu, Xueling Wu, Ying Jiang, Yuandong Liu, Yili Liang, Xueduan Liu, Huaqun Yin, Ngom Baba. Differential gene expression and bioinformatics analysis of copper-resistance gene afe_1073 in Acidithiobacillus ferrooxidans. Biological Trace Element Research. 2013,152(1):91-97.

Cheng-gui Zhang, Jin-lan Xia, Yuan-dong Liu, Huan He, Guan-zhou Qiu. The putative thiol-disulphide interchange protein DsbG from Acidithiobacillus ferrooxidans has disulphide isomerase activity. SCIENCEASIA, 2010, Volume: 36, Issue: 2, Pages: 100-104.  

Wu Xue-ling, Miao Bo, Han Jian, Hu Qi, Zeng Jia, Liu Yuan-dong, Qiu Guan-zhou. Purification and enzymatic properties of arsenic resistance protein ArsH from heterogeneous expression in E. coli BL21 . TRANSACTIONS OF NONFERROUS METALS SOCIETY OF CHINA, 2010. Volume: 20, Issue: 10, Pages: 1987-1992.

Chenbing Ai, Hongyu Mo, Chen, Qian Chen, Yuandong Liu, Lin Tang, Juan Du, Jia Zeng. Expression, Purification, and Characterization of an Iron Chaperon Protein CyaY from Acidithiobacillus ferrooxidans.  CURRENT MICROBIOLOGY. Volume: 62, Issue: 3,Pages: 733-738.

Yuandong Liu, Guanzhou Qiu. Structure prediction and docking study of RpiA from extremophile Acidithiobacillus ferrooxidans. Biohydrometallurgy: Biotech key to unlock mineral resources value (Proceedings of the 19th International Biohydrometallurgy Symposium). 393-399. September 18-22,2011.

Yuandong Liu, Guanzhou Qiu, Weimin Zeng. Grand Challenges for Bioleaching. Biohydrometallurgy: Biotech key to unlock mineral resources value (Proceedings of the 19th International Biohydrometallurgy Symposium). 341-343. September 18-22,2011.

CHEN Fengju，LIU Yuandong，GAO Jian，SUN Yuandon. Homology Modeling of RpiA from Acidithiobacillus ferrooxidans. ACTA SCIENTIARUM NATURALIUM UNIVERSITATIS SUNYATSENI. 49 (4): 294-300. Jul. 2010

Jia Zeng, Qing Liu, Xiaojian Zhang, Hongyu Mo, Yiping Wang, Qian Chen, Yuandong Liu. Functional Roles of the Aromatic Residues in the Stabilization of the [Fe4S4] Cluster in the Iro Protein from Acidithiobacillus ferrooxidans. Journal of Microbiology and Biotechnology, 20 (2): 294-300 FEB 2010

Yuandong Liu, Leping Zeng，Guanzhou Qiu*. Homology modeling and substrate binding study of glutathione reductase from Acidithiobacillus ferrooxidans. Progress in Modern Biomedicine. 2009,9(3):401-406

Yanjie Luo, Chenggui Zhang, Yuandong Liu, Xueling Wu, Hao Guan, Hehuan Liao, Hailang Luo, Xueduan Liu, Guanzhou Qiu. Differences between two copper related genes in the genome of Acidithiobacillus ferrooxidans. Biotechnology. 2009,19(2): 9-13

Chunli Zheng, Yanfei Zhang, Yuandong Liu, Anna Wu, Lexian Xia, Jia Zeng, Jianshe Liu,Guanzhou Qiu. Characterization and Reconstitute of a [Fe4S4] Adenosine 5 '-Phosphosulfate Reductase from Acidithiobacillus ferrooxidans. Current Microbiology, 2009,58 (6): 586-592.  JUN 2009

Yuandong Liu，Jian Gao, Jia Zeng, Chenggui Zhang, Xudong Ou Yang, Guanzhou Qiu* . Expression, purification and molecular modeling of iron-containing superoxide dismutase from  Acidithiobacillus ferrooxidans. Transactions of Nonferrous Metals Society of China.Volume 18, Issue 6, December 2008, Pages 1361-1366

WU An-na, ZHANG Yan-fei, ZHENG Chun-li, DAI Yun-jie, LIU Yuan-dong , ZENG Jia, GU Guo-hua, LIU Jian-she. Purification and enzymatic characteristics of cysteine desulfurase, IscS, in Acidithiobacillus ferrooxidans ATCC 23270. Transactions of Nonferrous Metals Society of China.Volume 18, Issue 6, December 2008, Pages 1450-1457

LIU Yuan-dong, QIU Guan-zhou*, WANG Hai-dong, JIANG Ying, ZHANG Cheng-gui, XIA Le-xian. Full Structure building and docking studies of NifS from extremophile Acidithiobacillus ferrooxidans.Transactions of Nonferrous Metals Society of China. 2008, 18(4):995-1002. AUG 2008

Jia Zeng,Long Wu, Xiaojian Zhang,Yuandong Liu,Guisheng Deng, Ding Li . Oct-2-en-4-ynoyl-CoA as a specific inhibitor of acyl-CoA oxidase. Organic Letters. 2008，10(19):4287-4290. OCT 2 2008

Yanjie Luo, Yuandong Liu, Chenggui Zhang, Hailang Luo, Hao Guan, Hehuan Liao, Guanzhou Qiu, Xueduan Liu. Insights into two high homogenous genes involved in copper homeostasis in Acidithiobacillus ferrooxidans.Current Microbiology. 2008, 57(4): 274-280. OCT 2008

Huidan Jiang, Zhang, Xiaojian Zhang, Chenbing Ai, Yuandong Liu, Jianshe Liu, Guanzhou Qiu, Jia Zeng. Asp97 is a crucial residue involved in the ligation of the [Fe4S4] cluster of IscA from Acidithiobacillus ferrooxidans. Journal of Microbiology and biotechnology. 2008,18 (6): 1070-1075. JUN 2008

[13] Jia Zeng, Huidan Jiang, Yuandong Liu, Jianshe Liu, Guanzhou Qiu. Expression, purification and characterization of a high potential iron-sulfur protein from Acidithiobacillus ferrooxidans. Biotechnology Letters. 2008, 30(5): 905-910. MAY 2008

LIU Yuan-dong, DING Jian-nan, QIU Guan-zhou*, WANG Hai-dong. Homology modeling and docking studies of IscS from extremophile Acidithiobacillus ferrooxidans. Journal of Central South University of Technology. 2007, 14(6):742-749. DEC 2007

Jia Zeng, Yuandong Liu, Long Wu, Ding Li. Mutation of Tyr375 to Lys375 allows medium-chain acyl-CoA dehydrogenase to acquire acyl-CoA oxidase activity. Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics. 2007,1774(12): 1628-1634. DEC 2007

LIU Yuan-dong, WANG Hai-dong, QIU Guan-zhou*. Homology modeling and evolutionary trace analysis of superoxide dismutase from extremophile Acidithiobacillus ferrooxidans. Journal of Central South University of Technology. 2007, 14(5):612-617. OCT 2007

Jia Zeng, Xia Huang, Yuandong Liu, Jianshe Liu, Guanzhou Qiu. Expression, Purification, and Characterization of a [Fe(2)S(2)] Cluster Containing Ferredoxin from Acidithiobacillus ferrooxidans. Current Microbiology. 2007,55(6):518-523. DEC 2007

Jia Zeng, Wenjie Zhao, Yuandong Liu, Lexian Xia, Jianshe Liu, Guanzhou Qiu. Expression, purification and characterization of an iron-sulfur cluster assembly protein, IscU, from Acidithiobacillus ferrooxidans. Biotechnology Letters. 2007, 29(12):1965-1972. DEC 2007

Jia Zeng, Yanfei Zhang, Yuandong Liu, Xiaojian Zhang, Leixian Xia, Jianshe Liu, Guanzhou Qiu. Expression, purification and characterization of a cysteine desulfurase, IscS, from Acidithiobacillus ferrooxidans. Biotechnology Letters. 2007, 29(12):1983-1990. DEC 2007

Jia Zeng, Meimei Geng, Huidan Jiang, Yuandong Liu, Jianshe Liu,Guanzhou Qiu. The IscA from Acidithiobacillus ferrooxidans is an iron–sulfur protein which assemble the [Fe4S4] cluster with intracellular iron and sulfur. Archives of Biochemistry and Biophysics. 2007, 463(2):237-244. JUL 15 2007

Jia Zeng, Meimei Geng, Yuandong Liu, Lexian Xia, Jianshe Liu,Guanzhou Qiu. The sulfhydryl group of Cys138 of rusticyanin from Acidithiobacillus ferrooxidans is crucial for copper binding. Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics. 2007, 1774(4): 519-525. APR 2007

Jia Zeng, Meimei Geng, Yuandong Liu, Wenjie Zhao, Lexian Xia, Jianshe Liu, Guanzhou Qiu. Expression, purification and molecular modelling of the Iro protein from Acidithiobacillus ferrooxidans Fe-1. Protein Expression and Purification. 2007, 52(1):146-152. MAR 2007

 

Software Development: 

Big data platform framework system for leaching environment microbial Informatics, software copyright registration No.2021SR0251361

Program System for Kinetics Simulation and Data Analysis of electron Transfer REDOX protein. Software Copyright No. 2021SR0424913

Back-propagation Artificial neural network modeling software system. Software copyright Registration No. 2019SR0167159

Artificial Neural network forecasting System for cement clinker calcination Quality. Software Copyright: 2018SR904579

Montmorillonite modified neural network forecast software, software copyright registration number: 2018SR955240

Biological metallurgy bacteria resources Information Platform system, software copyright registration number: 2019SR0393187

International Society of Biological Hydrometallurgy Information platform System, software copyright registration number: 2019SR0187548

The 19th International Conference on Biological Hydrometallurgy, Software copyright registration number: 2018SR1067535

Biological metallurgical laboratory information release platform system, software copyright registration No. : 2016SR074704

Multi-functional international real-time flexible and efficient web framework system, software copyright registration number: 2016SR073302,

Awards and honors:

Breeding of metallurgical microorganisms and leaching mechanism of sulfide ore under moderate high temperature, Science and Technology Award Work Office of Hunan Province, 2014 Natural Science Award of Hunan Province (Second Prize), 2014

Application driven Innovation in Bioinformatics Teaching, Teaching and Research Results of Basic Education Curriculum Reform, China Society for Education Development, 2013