马健，男，医学博士，研究员，博士生导师。现任中南大学肿瘤研究所副所长、非可控性炎症与肿瘤湖南省重点实验室副主任、湖南省免疫学会副理事长。本科毕业于湖南医科大学，博士毕业于中南大学肿瘤研究所。入选“教育部新世纪优秀人才支持计划”，获得湖南省杰出青年基金资助。获得湖南省自然科学奖二等奖。

先后主持了7项国家自然科学基金，并参加了数项国家自然科学基金重点项目、973项目和863项目。论文发表在Advanced Science、Journal of Hematology & Oncology、Oncogene、International Journal of Cancer、Journal of Cell Science、Journal of Virology、Journal of Biological Chemistry、Journal of Immunology等杂志。参编专（译）著5 部：《基于WWW的生物信息学应用指南》、《现代肿瘤学基础》、《病理生理学》、《癌症-基础卷》和《非编码RNA与肿瘤》。

课题组主要研究方向：

  (1) EB病毒感染与肿瘤免疫的机制研究。

  (2) 利用小鼠模型和临床样本，研究炎症-恶性转化过程中的关键分子、关键信号通路和可能的靶向策略。

  (3) 近年来对a) Hippo通路的YAP分子，b) 在肿瘤发生、发展中发挥重要功能的EphA2分子，c) 在天然免疫中发挥重要作用的天然免疫分子Lactoferrin进行了重点研究。

Email: majian@csu.edu.cn

近年发表的主要论文（*为通讯作者）:

1)      Peng Q, Wang L, Wang J, Liu C, Zheng X, Zhang X, Wei L, Li Z, Wu Y, Wen Y, Cao P, Liao Q, Yan Q*, Ma J*. Epstein-Barr Virus EBNA2 Phase Separation Regulates Cancer-associated Alternative RNA Splicing Patterns. Clinical and Translational Medicine. 2021;11(8):e504. PMID: 34459139. 

2)       Peng Q, Zhou Y, Oyang L, Wu N, Tang Y, Su M, Luo X, Wang Y, Sheng X, Ma J*. Liao Q*. Impacts and mechanisms of alternative mRNA splicing in cancer metabolism, immune response, and therapeutics. Molecular Therapy. 2021: S1525-0016(21)00581-5. PMID: 34793975

3)       Li Z, Zhang X, Liu C, Peng Q, Wu Y, Wen Y, Zheng R, Yan Q, Ma J*. Macrophage-biomimetic nanoparticles ameliorate ulcerative colitis through reducing inflammatory factors expression. Journal of Innate Immunity. 2021;1-13. PMID: 34724662

4)      Ou C, Sun Z, He X, Li X, Fan S, Zheng X, Peng Q, Li G, Li X*, Ma J*. Targeting YAP1/LINC00152/FSCN1 signaling axis prevents the progression of colorectal cancer. Advanced Science. 2019; 7(3): 1901380. PMID: 32042551

5)      Wei L, Liu C, Wang J, Zheng X, Peng Q, Ye Q, Qin Z, Li Z, Zhang X, Wu Y, Wen Y, Zhang X, Yan Q, Ma J*. Lactoferrin is required for early B cell development in C57BL/6 mice. Journal of Hematology & Oncology. 2021 Apr 7;14(1):58. PMID: 33827645.  

6)      Wei L, Zhang X, Wang J, Ye Q, Zheng X, Peng Q, Zheng Y, Liu P, Zhang X, Li Z, Liu C, Yan Q, Li G, Ma J*. Lactoferrin deficiency induces a pro-metastatic tumor microenvironment through recruiting myeloid–derived suppressor cells in mice. Oncogene. Oncogene. 2020; 39(1): 122-135. PMID: 31462711

7)      Zheng X, Wang J, Zhang X, Fu Y, Peng Q, Lu J. Wei L. Li Z, Liu C, Wu Y, Yan Q*, Ma J*. RNA m6A methylation regulates virus–host interaction and EBNA2 expression during Epstein–Barr virus infection. Immunity, Inflammation and Disease. 2021;9(2):351-362, PMID: 33434416. 

8)      Peng Q, Wang L, Qin Z, Wang J, Zheng X, Wei L, Zhang X, Zhang X, Liu C, Li Z, Wu Y, Li G, Yan Q*, Ma J*. Phase separation of Epstein-Barr Virus EBNA2 and Its Coactivator EBNALP controls gene expression. Journal of Virology. 2020; 94(7): e01771-19. PMID: 31941785.  

9)      Li Z, Wang J, Zhang X, Liu P, Zhang X, Wang J, Zheng X, Wei L, Peng Q, Liu C,Yan Q, Shen S, Li X*, Ma J*. Proinflammatory S100A8 Induces PD-L1 Expression in Macrophages, Mediating Tumor Immune Escape. Journal of Immunology. 2020 May 1;204(9):2589-2599. PMID: 32198140.  

10)    Wang J, Zheng X, Qin Z, Wei L, Lu Y, Peng Q, Gao Y, Zhang X, Zhang X, Li Z, Fu Y, Liu P, Liu C, Yan Q, Xiong W, Li G, Lu J*, Ma J*. Epstein-Barr virus miR-BART3-3p promotes tumorigenesis by regulating the senescence pathway in gastric cancer. Journal of Biological Chemistry. 2019;294(13):4854–4866. PMID: 30674552

11)    Zheng X, Wang J, Wei L, Peng Q, Gao Y, Fu Y, Lu Y, Qin Z, Zhang X, Lu J, Ou C, Li Z, Zhang X, Liu P, Xiong W, Li G, Yan Q, Ma J*. Epstein-Barr Virus miR-BART5-3p inhibits p53 expression. Journal of Virology. 2018; 92(23): e01022-18. PMID: 30209170.

12)    Peng Q, Chen L, Wu W, Wang J, Zheng X, Chen Z, Jiang Q, Han J, Wei L, Wang L, Huang J*, Ma J*. EPH receptor A2 governs a feedback loop that activates Wnt/β-catenin signaling in gastric cancer. Cell Death & Disease. 2018;9(12):1146. PMID: 30451837

13)    Wang S, Song R, Wang Z, Jing Z, Wang S, Ma J*. S100A8/A9 in Inflammation. Frontiers in Immunology. 2018; 9:1298. PMID: 29942307.

14)    Ou C, Sun Z, Li X, Li X, Ren W, Qin Z, Zhang X, Yuan W, Wang J, Yu W, Zhang S, Peng Q, Yan Q, Xiong W, Li G*, Ma J*. MiR-590-5p, a density-sensitive microRNA, inhibits tumorigenesis by targeting YAP1 in colorectal cancer. Cancer Letters. 2017; 399: 53-63. PMID: 28433598.

15)    Zhang X, Wei L, Wang J, Qin Z, Wang J, Lu Y, Zheng X, Peng Q, Ye Q, Ai F, Liu P, Wang S, Li G, Shen S, Ma J*. Suppression colitis and colitis-associated colon cancer by anti-S100a9 antibody in mice. Frontiers in Immunology. 2017; 8:1774. PMID: 29326691  

16)    Lu Y, Qin Z, Wang J, Zheng X, Lu J, Zhang X, Wei L, Peng Q, Zheng Y, Ou C, Ye Q, Xiong W, Li G, Fu Y, Yan Q*, Ma J*. Epstein-Barr Virus miR-BART6-3p Inhibits the RIG-I Pathway. Journal of Innate Immunity. 2017;9(6):574-586. PMID: 28877527.

17)    Ren W, Shen S, Sun Z, Shu P, Shen X, Bu C, Ai F, Zhang X, Tang A, Tian L, Li G, Li X*, Ma J*. Jak-STAT3 pathway triggers DICER1 for proteasomal degradation by ubiquitin ligase complex of CUL4ADCAF1 to promote colon cancer development. Cancer Letters. 2016; 375(2): 209-220. PMID: 26965998.

18)    Qin Z, He W, Tang J, Ye Q, Dang W, Lu Y, Wang J, Li G, Yan Q*, Ma J*. MicroRNAs provide feedback regulation of epithelial-mesenchymal transition induced by growth factors. Journal of Cellular Physiology. 2016; 231(1):120-129. PMID: 26032086.

19)    Zhang X, Ai F, Li X, She X, Li N, Tang A, Qin Z, Ye Q, Tian L, Li G, Shen S*, Ma J*. Inflammation-induced S100A8 activates Id3 and promotes colorectal tumorigenesis. International Journal of Cancer. 2015;137(12):2803-14. PMID: 26135667.

20)    Zheng Y, Qin Z, Ye Q, Chen P, Wang Z, Yan Q, Luo Z, Liu X, Zhou Y, Xiong W, Ma J*, Li G*. Lactoferrin suppresses the Epstein-Barr virus-induced inflammatory response by interfering with pattern recognition of TLR2 and TLR9. Laboratory Investigation.2014;94(11): 1188-1199. PMID: 25068657.  

21)    Deng M, Zhang W, Tang H, YeQ, Liao Q, Zhou Y, Wu M, Xiong W, Zheng Y, Guo X, Qin Z, He W, Zhou M, Xiang J, Li X, Ma J*, Li G*. Lactotransferrin acts as a tumor suppressor in nasopharyngeal carcinoma by repressing AKT through multiple mechanisms. Oncogene. 2013; 32(36): 4273-4283. PMID: 23069661.

22)    Tang A, Li N, Li X, Yang H,Wang W, Zhang L, Li GY, Xiong W, Ma J*, Shen S*. Dynamic activation of the key pathways: linking colitis to colorectal cancer in a mouse model. Carcinogenesis.2012, 33(7): 1375-1383. PMID: 22610167.

23)    Zheng Y, Zhang W,Ye Q, ZhouY, Xiong W, He W, Deng M, Zhou M, GuoX, Chen P, Fan S, Liu X, Wang Z, Li X, Ma J*,Li G*. Inhibition of Epstein-Barr virus infection by lactoferrin. Journal of Innate Immunity. 2012,4(4): 387-398. PMID: 22433582.

24)    Deng M, Tang H, Zhou Y, ZhouM, Xiong W, Zheng Y, Ye Q, Zeng X, Liao Q, Guo X, Li X, Ma J*, Li G*. MiR-216b suppresses tumor growth and invasion by targeting KRAS in nasopharyngeal carcinoma. Journal of Cell Science. 2011; 124(17): 2997-3005. PMID: 21878506.