马健，男，医学博士，博士生导师。现任中南大学肿瘤研究所研究员、非可控性炎症与肿瘤湖南省重点实验室副主任、湖南省免疫学会副理事长、中国免疫学会基础免疫分会理事。本科毕业于湖南医科大学，博士毕业于中南大学肿瘤研究所。获得湖南省自然科学奖二等奖。

先后主持了8项国家自然科学基金，并参加了数项国家自然科学基金重点项目、973项目和863项目。论文发表在Advanced Science、Journal of Hematology & Oncology、Oncogene、International Journal of Cancer、Journal of Cell Science、Journal of Virology、Journal of Biological Chemistry、Journal of Immunology等杂志。参编专（译）著5 部：《基于WWW的生物信息学应用指南》、《现代肿瘤学基础》、《病理生理学》、《癌症-基础卷》和《非编码RNA与肿瘤》。

课题组主要研究方向：

  (1) EB病毒感染与肿瘤免疫的机制研究。

  (2) 利用小鼠模型和临床样本，研究炎症-恶性转化过程中的关键分子、关键信号通路和可能的靶向策略。

Email: majian@csu.edu.cn

近年发表的主要论文（*为通讯作者）:

l  Hu Z, Li W, Wei L*, Ma J*. Lactoferrin in cancer: focus on mechanisms and translational medicine. Biochimica et Biophysica Acta- Reviews on Cancer. 2025. Apr 22;1880(3):189330. PMID: 40274081

l  Jiang J, Zhu X, Li S, Yan Q*, Ma J*. Building a bridge between the mechanism of EBV reactivation and the treatment of EBV-associated cancers. Journal of Medical Virology. 2025 Feb;97(2):e70192. PMID: 39868897

l  Li Z, Zhang X, Liu C, Wu Y, Wen Y, Zheng R, Xu C, Tian J, Peng Q, Zheng X, Wang J, Yan Q, Wei L*, Ma J*. Engineering a Nano-drug Delivery System to Regulate m6A Modification and Enhance Immunotherapy in Gastric Cancer. Acta Biomaterialia. 2024 Nov 22:S1742-7061(24)00689-5. 2025,191:412-427. PMID: 39581334

l  邓红雨*, 卢建红*, 冯琳*, 马健*. EB病毒的潜伏-裂解感染: 调控机制与靶向策略. 中国科学：生命科学. 2024, 54(12): 2274–2287. 

l  Zhang X, Li Z, Peng Q, Liu C, Wu Y, Wen Y, Zheng R, Xu C, Tian J, Zheng X, Yan Q, Wang J*, Ma J*. Epstein-Barr virus suppresses N6-Methyladenosine modification of TLR9 to promote immune evasion. Journal of Biological Chemistry. 2024 Mar 25; 300(5): 107226.  PMID: 38537697. 

l  Wen Y, Ye S, Li Z, Zhang X, Liu C, Wu Y, Zheng R, Xu C, Tian J, Shu L, Yan Q, Ai F*, Ma J*. HDAC6 inhibitor ACY-1215 enhances STAT1 acetylation to block PD-L1 for colorectal cancer immunotherapy. Cancer Immunology Immunotherapy. 2024 Jan 17;73(1):7. PMID: 38231305. 

l  Wu Y, Zhang X, Liu C, Li Z, Wen Y, Zheng R, Xu C, Tian J, Wei L, Wang J, Yan Q*, Zheng X*, Ma J* Epstein-Barr virus microRNA miR-BART2-5p accelerates nasopharyngeal carcinoma metastasis by suppressing RNase Ⅲ endonuclease DICER1. Journal of Biological Chemistry. 2023 Jul 24;299(9):105082. PMID: 37495108. 

l  Zhang X, Zheng R, Li Z, Ma J*. Liquid-liquid Phase Separation in Viral Function. Journal of Molecular Biology. 2023 Aug 15;435(16):167955. PMID: 36642156  

l  Tian J, Ma J*. The Value of Microbes in Cancer Neoantigen Immunotherapy. Pharmaceutics. 2023 Aug 14;15(8):2138; PMID: 37631352

l  Chen Y, Ouyang Y, Li Z, Wang X, Ma J*. S100A8 and S100A9 in Cancer. Biochimica et Biophysica Acta- Reviews on Cancer. 2023 May;1878(3):188891. PMID: 37001615.

l  Huang J, Zhao G, Peng Q, Yi X, Ji L, Li J, Li P, Guan Y, Ge J, Chen L, Chen R, Hu X, Lee WC, Reuben A, Futreal PA, Xia X, Ma J*, Zhang J*, Chen Z*. Analysis of genomic and immune intratumor heterogeneity in linitis plastica via multiregional exome and T-cell-receptor sequencing. Molecular Oncology. 2023 Aug;17(8):1531-1544. PMID: 36703611  

l  Wen Y, Ma J*. Phase separation drives the formation of biomolecular condensates in the immune system. Frontiers in Immunology. 2022 Nov 10;13:986589. PMID: 36439121

l  Zheng R, Ma J*. Immunotherapeutic implications of Toll-like receptors activation in tumor microenvironment. Pharmaceutics. 2022 Oct 25;14(11):2285.  PMID: 36365103 

l  Liu C, Peng Q, Wei L, Li Z, Zhang X, Wu Y, Wang J, Zheng X, Wen Y, Zheng R, Yan Q, Ye Q*, Ma J*. Deficiency of Lactoferrin aggravates lipopolysaccharide-induced acute inflammation via recruitment macrophage in mice. Biometals. 2023 Jun;36(3):549-562. PMID: 35650365

l  胡尔雅, 周敏, 曾雯辉, 罗燕, 严紫东, 马健*. 新冠病毒变异体对全球疫情防控的影响分析.生物化学与生物物理进展. 2022, 49(10):1827-1847. 

l  Peng Q, Zhou Y, Oyang L, Wu N, Tang Y, Su M, Luo X, Wang Y, Sheng X, Ma J*. Liao Q*. Impacts and mechanisms of alternative mRNA splicing in cancer metabolism, immune response, and therapeutics. Molecular Therapy. 2022 Mar 2;30(3):1018-1035. PMID: 34793975

l  Peng Q, Wang L, Wang J, Liu C, Zheng X, Zhang X, Wei L, Li Z, Wu Y, Wen Y, Cao P, Liao Q, Yan Q*, Ma J*. Epstein-Barr Virus EBNA2 Phase Separation Regulates Cancer-associated Alternative RNA Splicing Patterns. Clinical and Translational Medicine. 2021;11(8):e504. PMID: 34459139. 

l  Peng Q, Zhou Y, Oyang L, Wu N, Tang Y, Su M, Luo X, Wang Y, Sheng X, Ma J*. Liao Q*. Impacts and mechanisms of alternative mRNA splicing in cancer metabolism, immune response, and therapeutics. Molecular Therapy. 2021: S1525-0016(21)00581-5. PMID: 34793975

l  Li Z, Zhang X, Liu C, Peng Q, Wu Y, Wen Y, Zheng R, Yan Q, Ma J*. Macrophage-biomimetic nanoparticles ameliorate ulcerative colitis through reducing inflammatory factors expression. Journal of Innate Immunity. 2021;1-13. PMID: 34724662

l  Ou C, Sun Z, He X, Li X, Fan S, Zheng X, Peng Q, Li G, Li X*, Ma J*. Targeting YAP1/LINC00152/FSCN1 signaling axis prevents the progression of colorectal cancer. Advanced Science. 2019; 7(3): 1901380. PMID: 32042551

l  Wei L, Liu C, Wang J, Zheng X, Peng Q, Ye Q, Qin Z, Li Z, Zhang X, Wu Y, Wen Y, Zhang X, Yan Q, Ma J*. Lactoferrin is required for early B cell development in C57BL/6 mice. Journal of Hematology & Oncology. 2021 Apr 7;14(1):58. PMID: 33827645.  

l  Wei L, Zhang X, Wang J, Ye Q, Zheng X, Peng Q, Zheng Y, Liu P, Zhang X, Li Z, Liu C, Yan Q, Li G, Ma J*. Lactoferrin deficiency induces a pro-metastatic tumor microenvironment through recruiting myeloid–derived suppressor cells in mice. Oncogene. Oncogene. 2020; 39(1): 122-135. PMID: 31462711

l  Zheng X, Wang J, Zhang X, Fu Y, Peng Q, Lu J. Wei L. Li Z, Liu C, Wu Y, Yan Q*, Ma J*. RNA m6A methylation regulates virus–host interaction and EBNA2 expression during Epstein–Barr virus infection. Immunity, Inflammation and Disease. 2021;9(2):351-362, PMID: 33434416. 

l  Peng Q, Wang L, Qin Z, Wang J, Zheng X, Wei L, Zhang X, Zhang X, Liu C, Li Z, Wu Y, Li G, Yan Q*, Ma J*. Phase separation of Epstein-Barr Virus EBNA2 and Its Coactivator EBNALP controls gene expression. Journal of Virology. 2020; 94(7): e01771-19. PMID: 31941785.  

l  Li Z, Wang J, Zhang X, Liu P, Zhang X, Wang J, Zheng X, Wei L, Peng Q, Liu C,Yan Q, Shen S, Li X*, Ma J*. Proinflammatory S100A8 Induces PD-L1 Expression in Macrophages, Mediating Tumor Immune Escape. Journal of Immunology. 2020 May 1;204(9):2589-2599. PMID: 32198140.  

l  Wang J, Zheng X, Qin Z, Wei L, Lu Y, Peng Q, Gao Y, Zhang X, Zhang X, Li Z, Fu Y, Liu P, Liu C, Yan Q, Xiong W, Li G, Lu J*, Ma J*. Epstein-Barr virus miR-BART3-3p promotes tumorigenesis by regulating the senescence pathway in gastric cancer. Journal of Biological Chemistry. 2019;294(13):4854–4866. PMID: 30674552

l  Zheng X, Wang J, Wei L, Peng Q, Gao Y, Fu Y, Lu Y, Qin Z, Zhang X, Lu J, Ou C, Li Z, Zhang X, Liu P, Xiong W, Li G, Yan Q, Ma J*. Epstein-Barr Virus miR-BART5-3p inhibits p53 expression. Journal of Virology. 2018; 92(23): e01022-18. PMID: 30209170.

l  Peng Q, Chen L, Wu W, Wang J, Zheng X, Chen Z, Jiang Q, Han J, Wei L, Wang L, Huang J*, Ma J*. EPH receptor A2 governs a feedback loop that activates Wnt/β-catenin signaling in gastric cancer. Cell Death & Disease. 2018;9(12):1146. PMID: 30451837

l  Wang S, Song R, Wang Z, Jing Z, Wang S, Ma J*. S100A8/A9 in Inflammation. Frontiers in Immunology. 2018; 9:1298. PMID: 29942307.

l  Ou C, Sun Z, Li X, Li X, Ren W, Qin Z, Zhang X, Yuan W, Wang J, Yu W, Zhang S, Peng Q, Yan Q, Xiong W, Li G*, Ma J*. MiR-590-5p, a density-sensitive microRNA, inhibits tumorigenesis by targeting YAP1 in colorectal cancer. Cancer Letters. 2017; 399: 53-63. PMID: 28433598.

l  Zhang X, Wei L, Wang J, Qin Z, Wang J, Lu Y, Zheng X, Peng Q, Ye Q, Ai F, Liu P, Wang S, Li G, Shen S, Ma J*. Suppression colitis and colitis-associated colon cancer by anti-S100a9 antibody in mice. Frontiers in Immunology. 2017; 8:1774. PMID: 29326691  

l  Lu Y, Qin Z, Wang J, Zheng X, Lu J, Zhang X, Wei L, Peng Q, Zheng Y, Ou C, Ye Q, Xiong W, Li G, Fu Y, Yan Q*, Ma J*. Epstein-Barr Virus miR-BART6-3p Inhibits the RIG-I Pathway. Journal of Innate Immunity. 2017;9(6):574-586. PMID: 28877527.

l  Ren W, Shen S, Sun Z, Shu P, Shen X, Bu C, Ai F, Zhang X, Tang A, Tian L, Li G, Li X*, Ma J*. Jak-STAT3 pathway triggers DICER1 for proteasomal degradation by ubiquitin ligase complex of CUL4ADCAF1 to promote colon cancer development. Cancer Letters. 2016; 375(2): 209-220. PMID: 26965998.

l  Qin Z, He W, Tang J, Ye Q, Dang W, Lu Y, Wang J, Li G, Yan Q*, Ma J*. MicroRNAs provide feedback regulation of epithelial-mesenchymal transition induced by growth factors. Journal of Cellular Physiology. 2016; 231(1):120-129. PMID: 26032086.

l  Zhang X, Ai F, Li X, She X, Li N, Tang A, Qin Z, Ye Q, Tian L, Li G, Shen S*, Ma J*. Inflammation-induced S100A8 activates Id3 and promotes colorectal tumorigenesis. International Journal of Cancer. 2015;137(12):2803-14. PMID: 26135667.

l  Zheng Y, Qin Z, Ye Q, Chen P, Wang Z, Yan Q, Luo Z, Liu X, Zhou Y, Xiong W, Ma J*, Li G*. Lactoferrin suppresses the Epstein-Barr virus-induced inflammatory response by interfering with pattern recognition of TLR2 and TLR9. Laboratory Investigation.2014;94(11): 1188-1199. PMID: 25068657.  

l  Deng M, Zhang W, Tang H, YeQ, Liao Q, Zhou Y, Wu M, Xiong W, Zheng Y, Guo X, Qin Z, He W, Zhou M, Xiang J, Li X, Ma J*, Li G*. Lactotransferrin acts as a tumor suppressor in nasopharyngeal carcinoma by repressing AKT through multiple mechanisms. Oncogene. 2013; 32(36): 4273-4283. PMID: 23069661.

l  Tang A, Li N, Li X, Yang H,Wang W, Zhang L, Li GY, Xiong W, Ma J*, Shen S*. Dynamic activation of the key pathways: linking colitis to colorectal cancer in a mouse model. Carcinogenesis.2012, 33(7): 1375-1383. PMID: 22610167.

l  Zheng Y, Zhang W,Ye Q, ZhouY, Xiong W, He W, Deng M, Zhou M, GuoX, Chen P, Fan S, Liu X, Wang Z, Li X, Ma J*,Li G*. Inhibition of Epstein-Barr virus infection by lactoferrin. Journal of Innate Immunity. 2012,4(4): 387-398. PMID: 22433582.

l  Deng M, Tang H, Zhou Y, ZhouM, Xiong W, Zheng Y, Ye Q, Zeng X, Liao Q, Guo X, Li X, Ma J*, Li G*. MiR-216b suppresses tumor growth and invasion by targeting KRAS in nasopharyngeal carcinoma. Journal of Cell Science. 2011; 124(17): 2997-3005. PMID: 21878506.