王建秀

个人简介

王建秀，男，教育部新世纪优秀人才，中南大学二级教授，中南大学首批“升华学者计划”特聘教授。北京大学博士、中国科学院博士后。2004年被聘为中南大学化学化工学院教授，2005年起任分析化学学科博士生导师，入选中南大学531人才计划第二层次。2005年入选中南大学首批“升华学者计划”特聘教授，2009年度入选教育部“新世纪优秀人才支持计划”,  2014年起任中南大学二级教授。研究方向为生物传感器研发、联用仪器的开发以及重大疾病致病机理研究。在Anal. Chem., Chem. Commun., ACS Sensors, ACS Applied Materials & Interfaces 等国际知名刊物上发表SCI论文130余篇，被SCI引用4940余次。应邀为国际知名出版社John Wiley & Sons, Inc., American Chemical Society等撰写书籍的章节4部。以第一发明人身份授权国家发明专利10余项。主持国家自然科学基金面上项目、国家自然科学基金外国青年学者研究基金、教育部“新世纪优秀人才支持计划”项目、教育部博士点基金项目以及横向项目等20余项。荣获湖南省自然科学二等奖一项（排名第一）、三等奖两项（排名第一和第三）、教育部自然科学二等奖（排名第四）、以及湖南省第十三届和第十五届自然科学优秀学术论文一等奖（均排名第一）。

代表性科研论文及专著 (均为第一作者或通讯作者）

[1] Jianxiu Wang, M. Li, Z. Shi, N. Li, Z. Gu, Direct electrochemistry of cytochrome c at a glassy carbon electrode modified with single-wall carbon nanotubes. Anal. Chem. 2002, 74, 1993-1997.
[2] Jianxiu Wang, X. Zhu, Q. Tu, Q. Guo, C. S. Zarui, J. Momand, X. Sun, F. Zhou, Capture of p53 by electrodes modified with consensus DNA duplexes and amplified voltammetric detection using ferrocene-capped gold nanoparticle/streptavidin conjugates. Anal. Chem. 2008, 80, 769-774.
[3] Y. Wang, X. Zhu, M. Wu, N. Xia, J. Wang, F. Zhou, Simultaneous and label-free determination of wild-type and mutant p53 at a single SPR chip preimmobilized with consensus DNA and monoclonal antibody. Anal. Chem. 2009, 81, 8441-8446.
[4] Y. Long, D. Jiang, X. Zhu, J. Wang, F. Zhou, Trace Hg2+ analysis via quenching of the fluorescence of a CdS-encapsulated DNA nanocomposite. Anal. Chem. 2009, 81, 2652-2657. 

[5] Jianxiu Wang, et al., Improved electrochemistry of biomolecules using nanomaterials. Biosensing using nanomaterials Bionano, John Wiley & Sons, Inc. 2009, 99-136. (ISBN: 978-0-470-18309-0).

[6] N. Xia, L. Liu, M. Harrington, J. Wang, F. Zhou, Regenerable SPR sensors for simultaneous detection of Aβ(1–40) and Aβ(1–42) peptides in cerebrospinal fluids with signal amplification by streptavidin conjugated to an N-terminus-specific antibody. Anal. Chem. 2010, 82, 10151-10157.

[7]  Jianxiu Wang, et al., Quantum dot nanocomposites. Nanomaterials for life sciences, John Wiley & Sons, Inc. 2010, 169-197. (ISBN: 978-3-527-32168-1).

[8] Jianxiu Wang, Xinyao Yi, Hailin Tang, Hongxing Han, Minghua Wu, Feimeng Zhou, Direct quantification of microRNA at low pM level in sera of glioma patients using a competitive hybridization followed by amplified voltammetric detection, Anal. Chem. 2012, 84, 6400-6406.
[9] Xinyao Yi, Yuanqiang Hao, Ning Xia, Jianxiu Wang, Monica Quintero, Ding Li, Feimeng Zhou, Sensitive and Continuous Screening of Inhibitors of β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) at Single SPR Chips, Anal. Chem. 2013, 85, 3660-3666. 

[10] Chen, Xiaolan; He, Chuhua; Zhang, Zhifan, Wang, Jianxiu, Sensitive chemiluminescence detetion of wild-type p53 protein captured by surface-confined consensus DNA duplexes, Biosens. Bioelectron., 2013, 47, 335-339.

[11] Yuanqiang Hao, Lin Liu, Yunfei Long, Jianxiu Wang, You-Nian Liu, Feimeng Zhou, Sensitive Photoluminescent Detection of Cu²⁺ in Real Samples Using CdS Quantum Dots in Combination with a Cu²⁺-Reducing Reaction, Biosens. Bioelectron., 2013, 41,723-729.

[12] Xinyao Yi, Hongxing Han, Yu Zhang, Jianxiu Wang, Yi Zhang, Feimeng Zhou, Amplified voltammetric characterization of cleavage of the biotinylated peptide by BACE1 and screening of BACE1 inhibitors, Biosens. Bioelectron., 2013, 50, 224-228.

[13] Xiaodong Xia, Yuanqiang Hao, Shengqiang Hu, Jianxiu Wang, Hairpin DNA probe with 5'-TCC/CCC-3' overhangs for the creation of silver nanoclusters and miRNA assay,  Biosens. Bioelectron., 2014, 51, 36-39.

[14] Shen, Congcong; Xia, Xiaodong; Hu, Shengqiang; Yang, Minghui; Wang, Jianxiu, Silver nanoclusters-based fluorescence assay of protein kinase activity and inhibition, Anal. Chem. 2015, 87, 693-698. 

[15] Zhixuan Lu, Hailin Tang, Daohong Wu, Yonghong Xia, Minghua Wu, Xinyao Yi, Hengfeng Li, Jianxiu Wang, Amplified voltammetric detection of miRNA from serum samples of glioma patients via combination of conducting magnetic microbeads and ferrocene-capped gold nanoparticle/streptavidin conjugates, Biosens. Bioelectron., 2016, 86,502-507.

[16] Wang, Jingrui; Lu, Zhixuan; Tang, Hailin; Wu, Ling; Wang, Zixiao; Wu, Minghua; Yi, Xinyao; Wang, Jianxiu, Multiplexed Electrochemical Detection of MiRNAs from Sera of Glioma Patients at Different Stages via the Novel Conjugates of Conducting Magnetic Microbeads and Diblock Oligonucleotide-Modified Gold Nanoparticles, Anal. Chem., 2017, 89, 10834-10840.
[17] Xinyao Yi, Yonghong Xia, Binrong Ding, Ling Wu, Shengqiang Hu, Zixiao Wang, Jianxiu Wang, Dual-Channel Surface Plasmon Resonance for Quantification of ApoE Gene and Genotype Discrimination in Unamplified Genomic DNA Extracts. ACS Sensors, 2018, 3, 2402-2407.
[18] Hu, Shengqiang; Yi, Tiantian; Huang, Zhicheng; Liu, Biwu; Wang, Jianxiu; Yi, Xinyao; Liu, Juewen, Etching Silver Nanoparticles by Poly-Cytosine DNA, Materials Horizons, 2019, 6, 155-159.
[19] Hu, Shengqiang; Tong, Liujuan; Wang, Jianxiu; Yi, Xinyao; Liu, Juewen, NIR Light-Responsive Hollow Porous Gold Nanospheres for Controllable Pressure-based Sensing and Photothermal Therapy of Cancer Cells, Anal. Chem., 2019, 91, 15418-15424.
[20] Yonghong Xia, Ling Wu, Yuqing Hu, Yuhan He, Zhong Cao, Xu Zhu, Xinyao Yi, Jianxiu Wang, Sensitive Surface Plasmon Resonance Detection of Methyltransferase Activity and Screening of its Inhibitors Amplified by p53 Protein Conjugated to Methylation-Specific ds-DNA Consensus Sites, Biosens. Bioelectron., 2019, 126, 269-274.

[21] Shengqiang Hu, Jianxiu Wang, Juewen Liu, Unified Etching and Protection of Facet Silver Nanostructures by DNA, J. Phys. Chem. C, 2019, 123, 12015−12022.

[22] Shengqiang Hu, Po-Jung Jimmy Huang, Jianxiu Wang, Juewen Liu, Dissecting the Effect of Salt for more Sensitive Label-free Colorimetric Detection of DNA Using Gold Nanoparticles, Anal. Chem., 2020, 92, 13354-13360.

[23] Lu, Hanwen; Ding, Binrong; Wu, Fan; Yi, Xinyao; Wang, Jianxiu, Toehold-mediated strand displacement reaction for dual-signal electrochemical assay of apolipoprotein E genotyping, ACS sensors, 2020, 5, 2959-2965.

[24] Lu, Hanwen; Tang, Hailin; Yi, Xinyao; Wang, Jianxiu, Three-dimensional DNA nanomachine combined with toehold-mediated strand displacement reaction for sensitive electrochemical detection of miRNA, Langmuir, 2020, 36, 10708-10714.

[25] Zhaohui Wei, Yuefan Yu, Shengqiang Hu, Xinyao Yi, Jianxiu Wang, Bifunctional diblock DNA-mediated synthesis of nanoflower-shaped photothermal nanozymes for highly sensitive colorimetric assay of cancer cells, ACS Applied Materials & Interfaces, 2021, 13, 16801-16811.

[26] Fan Wu, Qicheng Zhang, Baohong Sun, Xiaohong Chu, Ming Zhang, Zhangcai She, Zihan Li, Ninglin Zhou, Jianxiu Wang, Ao Li, MoO_3-x nanosheets-based platform for single NIR laser induced efficient PDT/PTT of cancer, Journal of Controlled Release, 2021, 338, 46-55.

[27] Wenchao Chen, Zhilian Tang, Shengqiang Hu, Xinyao Yi, Jianxiu Wang, Ultraviolet C irradiation-induced dehybridization of double-stranded oligonucleotides: mechanism investigation and label-free measurement of photodamage level, Langmuir, 2022, 38, 15190-15197.

[28] Cheng, Qiang; Li, Yuyan; Huang, Wei; Li, Ke; Lan, Minhuan; Wang, Benhua; Wang, Jianxiu; Song, Xiangzhi, Copper Coordination-Based Conjugated Polymer Nanoparticles for Synergistic Photodynamic and Chemodynamic Therapy, Chem. Commun., 2023, 59, 5886-5889. 

[29] Han, Shaohui; Wang, Hong; Li, Haipu; Li, Ke; Wang, Jianxiu; Song, Xiangzhi, Construction of a Dual-Functional, Reversible, Ratiometric, Golgi-Targeting Fluorescent Probe for Real-time Monitoring of Dynamics of Intracellular Redox Homeostasis, Anal. Chem., 2023, 95, 8002-8010.

[30] Chengchen Tan, Guoyang Xie, Song Wu, Cailu Song, Jinhui Zhang, Xinyao Yi, Jianxiu Wang, Hailin Tang, Simultaneous detection of breast cancer biomarkers circROBO1 and BRCA1 based on a CRISPR-Cas13a/Cas12a system, Biosens. Bioelectron., 2024, 258, 116373.

教育经历

[1]   1988.9-1992.7

山西大学  |  分析化学  |  学士学位  |  大学本科毕业

[2]   1992.9-1995.6

西北大学  |  分析化学  |  硕士学位  |  硕士研究生毕业

[3]   1999.9-2002.6

北京大学  |  分析化学  |  博士学位  |  博士研究生毕业

[4]   2002.7-2004.4

中国科学院研究生院  |  分析化学  |  博士后

工作经历

[1]   1995.9-1999.7

太原理工大学  |  化学化工学院  |  讲师

[2]   2004.4-至今

中南大学  |  化学化工学院  |  教授/二级教授

研究方向

其他联系方式

团队成员

团队名称：生物传感与表面分析

团队介绍：研究生培养方面：
博士生24人，其中已毕业18人；
硕士生51人，其中已毕业44人