The association of adiponectin allele 45T/G and -11377C/G polymorphisms with Type 2 diabetes and rosiglitazone response in Chinese patients

Release time:2016-04-30

Affiliation of Author(s):Department of Pharmacy, Fujian Provincal Hospital

Teaching and Research Group:Department of Pharmacy,Fujian Provincal Hospital

Journal:british journal of clinical pharmacology

Place of Publication:britsh

Funded by:National Natural Science Foundation of China

Key Words:C-11377G polymorphism, T45G polymorphism, adiponectin, diplotype, rosiglitazone efficacy, Type 2 dia

Abstract:Abstract WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: Rosiglitazone is able to increase serum adiponectin levels significantly in Type 2 diabetic patients. :The role of genetic factors that determine the marked interindividual variability in glucose-lowering efficacy of rosiglitazone in Chinese patients is not known. The current study was designed to evaluate the impact of the adiponectin common allele 45T/G and -11377C/G polymorphisms on the response to rosiglitazone monotherapy in Chinese patients with Type 2 diabetes (T2D). WHAT THIS STUDY ADDS: The genetic polymorphisms of adiponectin allele

Co-author:Liu ZQ*, Wu J, Zhou HH, Guo ZW, Liu YZ, Liu HL, Yin JY, Gong ZC#, Sun H#*

Indexed by:Unit Twenty Basic Research

Document Code:DOI:10.1111/j.1365-2125.2008.03145.x

Discipline:临床医学

Document Type:J

Volume:65

Issue:6

Page Number:917-926

ISSN No.:1365-2125

Translation or Not:no

Date of Publication:2008-04-22

Links to published journals:http://www.ncbi.nlm.nih.gov/pubmed/?term=The+association+of+adiponectin+allele+45T%2FG+and+-11377C%2FG+polymorphisms+with+Type+2+diabetes+and+rosiglitazone+response+in+Chinese+patients.