Rosiglitazone inhibits high glucose-induced apoptosis in human umbilical veinendothelial cells through PI3K/Akt/eNOS pathway

Release time:2016-05-23

Affiliation of Author(s):Department of Endocrinology, Xiang-Ya Hospital, Central South University

Teaching and Research Group:Department of Endocrinology, Xiang-Ya Hospital, Ce

Journal:Can J Physiol Pharmacol.

Place of Publication:canada

Funded by:National Natural Science Foundation of China (No. 30801395)

Key Words:rosiglitazone, PI3K, Akt, eNOS, NO, caspase-3

Abstract:Abstract Previous studies have shown that the phosphatidylinositol 3-kinase / Akt / endothelial nitric oxide synthase / NO (PI3K/Akt/eNOS/NO) pathway is involved in high glucose-induced endothelial cell apoptosis and rosiglitazone has a protective effect on endothelium. In the present study, we investigated the antiapoptotic effect of rosiglitazone on human umbilical vein endothelial cells (HUVECs) exposed to high glucose and explored its possible mechanism. Treatment of high glucose (33 mmol/L) for 48 h significantly induced the apoptosis of HUVECs, concomitantly with increased caspase-3 ……

Indexed by:Unit Twenty Basic Research

Document Code:doi: 10.1139/y09-040

Discipline:临床医学

Document Type:J

Volume:87

Issue:7

Page Number:549-55

ISSN No.:doi: 10.1139/y09-040

Translation or Not:no

Date of Publication:2009-07-06

Links to published journals:http://www.ncbi.nlm.nih.gov/pubmed/?term=.Rosiglitazone+inhibits+high+glucose-induced+apoptosis+in+human+umbilical+veinendothelial+cells+through+PI3K%2FAkt%2FeNOS+pathway