Improved biological compatibility of carbon materials via aqua regia and CaCl2 treatments

Release time:2024-07-05

DOI number:10.1016/j.matchemphys.2023.127359

Journal:Materials Chemistry and Physics

Key Words:Single-phase carbon Hydroxyapatite Bioactivity Surface modiffcations Cell ultrastructure

Abstract:In order to improve the bioactivity of three single-phase carbon materials (resin, pyrocarbon and graphite), chemical modiffcation with aqua regia and CaCl2 solution was used to modify their original surfaces. The bioactivity of materials before and after modiffcation was evaluated by in vitro apatite formation in simulated body ffuids (SBF). The results showed that –COOH and Ca2+ were introduced on the sample surface by the chemical modiffcation. The treated resin demonstrated the strongest ability to form a uniform and dense HAP coating after soaking in SBF for its largest speciffc surface area and the highest content of -COO- . The bone-like apatite coating demonstrated remarkably enhanced in vitro biocompatibility as indicated in the mouse ffbroblast (L929) direct contact and ultrastructure observation. The transformation process of hydroxyapatite morphology in functional carbon materials, and the hydroxyapatite formation mechanism were systematically analyzed.

Indexed by:Article

Discipline:Engineering

First-Level Discipline:Materials Science and Engineering

Document Type:J

Volume:296

Page Number:127359

Translation or Not:no

Date of Publication:2023-01-06

Included Journals:SCI