Improved biological compatibility of carbon materials via aqua regia and CaCl2 treatments
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Release time:2024-07-05
DOI number:10.1016/j.matchemphys.2023.127359
Journal:Materials Chemistry and Physics
Key Words:Single-phase carbon
Hydroxyapatite
Bioactivity
Surface modiffcations
Cell ultrastructure
Abstract:In order to improve the bioactivity of three single-phase carbon materials (resin, pyrocarbon and graphite),
chemical modiffcation with aqua regia and CaCl2 solution was used to modify their original surfaces. The
bioactivity of materials before and after modiffcation was evaluated by in vitro apatite formation in simulated
body ffuids (SBF). The results showed that –COOH and Ca2+ were introduced on the sample surface by the
chemical modiffcation. The treated resin demonstrated the strongest ability to form a uniform and dense HAP
coating after soaking in SBF for its largest speciffc surface area and the highest content of -COO-
. The bone-like
apatite coating demonstrated remarkably enhanced in vitro biocompatibility as indicated in the mouse ffbroblast
(L929) direct contact and ultrastructure observation. The transformation process of hydroxyapatite morphology
in functional carbon materials, and the hydroxyapatite formation mechanism were systematically analyzed.
Indexed by:Article
Discipline:Engineering
First-Level Discipline:Materials Science and Engineering
Document Type:J
Volume:296
Page Number:127359
Translation or Not:no
Date of Publication:2023-01-06
Included Journals:SCI
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Improved biological compatibility of carbon materials via aqua regia and CaCl2 treatments-陈红梅.pdf
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