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李乾斌
— 博士生导师
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教师姓名：李乾斌
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职称：教授
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职务：博士生导师
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教师拼音名称：liqianbin
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所在单位：湘雅药学院
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学历：博士研究生毕业
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入职时间：2010-04-22
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学位：博士学位
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毕业院校：山东大学
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在职信息：在职
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学科：药学
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招生学科：药学
- Hu Y., Zhao C., Tan W., Li M., Wang Y., Gao R., Chen Z., Jin Z., Hu L., Li Q. Discovery and Optimization of Hsp110 and sGC Dual-Target Regulators for the Treatment of Pulmonary Arterial Hypertension. J Med Chem, 2024, 67(15): 13474-13490.
- Li J., Gao R., Zhao C., Xiang H., Le X., Zhang X., Cai Q., He L., Li Q., Hu L., Zou H. Inhibition of breast cancer growth with AN-329, a novel Hsp110 inhibitor, by inactivating p-STAT3/c-Myc axis. Biomed. Pharmacother., 2024, 181: 117694.
- Li M., Zhao C., Xiang H., Wang Y., Gao R., Cai Q., Chen Q., Chen Z., Hu L., Li Q. Design, synthesis and optimization of pyrazolo[3,4-b] pyridine derivatives as Hsp110-STAT3 interaction disruptors for the treatment of pulmonary arterial hypertension. Bioorg Chem, 2024, 153: 107888.
- Wang Z., Liu L., Liu E., Chen R., Huang Y., Li Q. Carrier Polymer-Free Dissolvable Microneedles Enable Superhigh Drug Payload for Percutaneous Protein Delivery. ACS Materials Letters, 2024, 6(11): 4980-4987.
- Wu S., Zhang L., Hao C., Ma B., Li Z., Fan S., Li Q., Hu G., Chen Z. Chromone Derivatives as a Novel NOX4 Inhibitor: Design, Synthesis, and Regulation of ROS in Renal Fibroblast. Chem. Biol. Drug Des., 2024, 104(5): e70015.
- Zhang L., Yang X., Yi R., Wu S., Li Q., Hu G., Chen Z. Design, Synthesis, and Biological Evaluation of Quinoline (Quinolinone) Derivatives as NADPH Oxidase (NOX) Inhibitors. Chem. Biol. Drug Des., 2024, 104(2): e14610.
- Zhao C., Wu Y., Li M., Tan W., Hu Y., Wang Y., Gao R., Hu L., Li Q. Allosteric site identification, virtual screening and discovery of a sulfonamide Hsp110-STAT3 interaction inhibitor for the treatment of hypoxic pulmonary arterial hypertension. Eur J Med Chem, 2024, 279: 116855.
- Zhao C., Xiang H., Li M., Gao R., Zhang Y., Li Q., Hu L. Heat shock protein 110: A novel candidate for disease diagnosis and targeted therapy. Drug Discov Today, 2024, 29(12): 104199.
- Cao M., Guo Y., Tan W., Feng C., Chen Q., Yao M., Xu J., Chen Z., Li Q. Novel sodium-hydrogen exchanger 1 inhibitors with diphenyl ketone scaffold: Design, Synthesis, mechanism and evaluation in mice model of heart failure. Eur J Med Chem, 2025, 291: 117585.
- Chen Q., Le X., Wen Q., Cao S., Guo Y., Weng X., Zhang L., Wei J., Zou M., Hu L., Li Q., Liu S., Chen Z. Discovery of Cdc20/Hsp90 Dual-Target Inhibitors with Potent Antitumor Activity for Therapy of Acquired Resistant Melanoma. J Med Chem, 2025, 68(21): 22428-22454.
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中南大学
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