DOI number:10.1016/j.jaad.2025.05.1395
Journal:J Am Acad Dermatol
Abstract:Background: The role of lifestyle factors in the progression of psoriatic diseases (PDs) and cardiometabolic diseases (CMDs) remains underexplored. Objective: To assess the impact of lifestyle factors on transitions from a disease-free state to PDs, CMDs, their multimorbidity, and death. Methods: We analyzed 379,874 UK Biobank participants. Lifestyle factors included smoking status, body mass index (BMI), physical activity, and diet. An ideal lifestyle was defined as never smoking, BMI < 25 kg/m2, and adequate physical activity. Multistate models were employed to evaluate their impacts on different transitions. Results: Over 12.1 years, 2500 PD and 34,619 CMD incident events occurred. An ideal lifestyle showed protective effects on PD incidence among disease-free individuals, CMD incidence and all-cause mortality among PD patients, and all-cause mortality among patients with PD and CMD multimorbidity; the corresponding hazard ratios (95% confidence intervals) were 0.43 (0.36-0.51), 0.40 (0.31-0.53), 0.50 (0.31-0.81), and 0.64 (0.39-1.05), compared with participants who were ever-smokers, BMI ≥ 25 kg/m2, and with inadequate physical activity. Ideal lifestyle added up to 5.3 years of life expectancy in PD participants. Limitations: No verification in other ascertained population. Conclusions: Lifestyles are modifiable determinants and nonpharmaceutical strategies for preventing cardiometabolic comorbidities and mortality of PDs.
Note:共同第一作者（2/2）
Indexed by:Journal paper
Document Code:PMID: 40383272
Document Type:J
Volume:93
Issue:3
Page Number:715-723
Translation or Not:no
Included Journals:SCI