中南大学 Songchun Yang

The Impact of Lifestyle Factors on Cardiometabolic Comorbidities and Mortality of Psoriatic Diseases: A Multi-State Model Analysis

Release time:2026-02-28

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Abstract:: Background: The role of lifestyle factors in the progression of psoriatic diseases (PDs) and cardiometabolic diseases (CMDs) remains underexplored. Objective: To assess the impact of lifestyle factors on transitions from a disease-free state to PDs, CMDs, their multimorbidity, and death. Methods: We analyzed 379,874 UK Biobank participants. Lifestyle factors included smoking status, body mass index (BMI), physical activity, and diet. An ideal lifestyle was defined as never smoking, BMI < 25 kg/m2, and adequate physical activity. Multistate models were employed to evaluate their impacts on different transitions. Results: Over 12.1 years, 2500 PD and 34,619 CMD incident events occurred. An ideal lifestyle showed protective effects on PD incidence among disease-free individuals, CMD incidence and all-cause mortality among PD patients, and all-cause mortality among patients with PD and CMD multimorbidity; the corresponding hazard ratios (95% confidence intervals) were 0.43 (0.36-0.51), 0.40 (0.31-0.53), 0.50 (0.31-0.81), and 0.64 (0.39-1.05), compared with participants who were ever-smokers, BMI ≥ 25 kg/m2, and with inadequate physical activity. Ideal lifestyle added up to 5.3 years of life expectancy in PD participants. Limitations: No verification in other ascertained population. Conclusions: Lifestyles are modifiable determinants and nonpharmaceutical strategies for preventing cardiometabolic comorbidities and mortality of PDs.