Release time:2016-05-06
Affiliation of Author(s):中南大学湘雅医院内分泌科
Teaching and Research Group:中南大学湘雅医院内分泌科
Journal:现代生物医学进展
Place of Publication:中国
Funded by:湖南省教育科学规划课题(重点项目),(XJK03AJ006)
Key Words:脂联素; 单核苷酸多态性; 肿瘤坏死因子-α; 儿童肥胖症
Abstract:脂联素(ADPN)是一种主要由脂肪细胞分泌的特异性细胞因子,参与机体的糖和脂肪代谢,随着脂肪组织的增多ADPN水平下降。人群中脂联素基因序列中存在相当数量的等位基因单核苷酸多态性(SNPS),脂联素基因的SNPs与儿童肥胖关系密切。肥胖儿童中肿瘤坏死因子-α(TNF-α)水平升高,限制肥胖的发展。脂联素和肿瘤坏死因子-α在机体内可相互影响表达,共同参与儿童肥胖的形成。
Co-author:颜伟健; 吴静
Indexed by:Other
Document Code:1673-6273(2008)11-2137-03
Discipline:临床医学
Document Type:J
Volume:8
Issue:11
Page Number:2137-2139
ISSN No.:1673-6273
Translation or Not:no
Date of Publication:2008-05-19
Links to published journals:http://www.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=1&dbcode=CJFQ&dbname=CJFD2008&filename=SWCX200811050&urlid=&yx=&uid=WEEvREcwSlJHSldSdnQ1ZThyUWFyb283azRPcnYvaUhMUXNZR3pncWRZbjFQSVI3a2NBeVV
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